Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b
Under an Elsevier user license
open archive
Highlights
► A novel gene, claudin 15-like b, is identified in zebrafish and has 2 isoforms. ► Cldn15lb is dynamically expressed in hepatocytes and biliary epithelial cells. ► Disruption of cldn15lb affects hepatocyte polarization and canaliculi formation. ► Biliary ducts in cldn15lb mutants do not remodel and form a disorganized network. ► Cldn15lb regulates cell behaviors during biliary duct morphogenesis.
Keywords
Claudin
Liver development
Zebrafish
Biliary duct remodeling
Biliary cells
Biliary duct morphogenesis
Tight junctions
Cholestasis
Cited by (0)
- 1
Current Address. Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Copyright © 2011 Elsevier Inc. All rights reserved.