ReviewCancer metabolism: The Warburg effect today
Research highlights
► Warburg first established a tumour metabolic pattern in the 1920s. ► Tumours' increased glucose uptake has been studied since then. ► Cancer bioenergetics' study provides insights in all its hallmarks. ► New cancer diagnostic and therapeutic techniques focus on cancer metabolism.
Abbreviations
CL
cardiolipin
EGFR
endothelial growth factors receptor
ETC
electron transport chain
FDG
18Fluoro-deoxy-glucose
F2,6BP
fructose 2,6-bisphosphate
GLUT
glucose facilitative transporter
GSK3
glycogen synthase kinase 3
HIF-1
hypoxia inducible factor 1
HK
hexokinase
MCT
monocarboxylate transporter
NHE-1
Na+/H+ exchanger 1
ODD
“Oxygen Dependent Degradation”
OXPHOS
oxidative phosphorylation
PDH
pyruvate dehydrogenase
PET
positron emission tomography
PFKFB
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
PFK-1
6-phosphofructo-1-kinase
PPP
pentose phosphate pathway
ROS
reactive oxygen species
SCO2
“Synthesis of Cytochrome c Oxidase 2”
TIGAR
TP53-induced glycolysis and apoptosis regulator
tPMET
trans-plasma membrane electron transporter
UCP2
mitochondrial uncoupling protein 2
VEGF
vascular endothelial growth factor
VHL
von Hippel-Lindau
Keywords
Cancer
Warburg effect
Metabolism
Microenvironment
Cited by (0)
Copyright © 2010 Elsevier Inc. All rights reserved.