Early invasive cervical cancer: MRI and CT predictors of lymphatic metastases in the ACRIN 6651/GOG 183 intergroup study
Section snippets
Methods
Each imaging site was required to have a proven record of 20 surgical cases of cervical cancer per year, 1.5 T MRI and helical CT equipment, and an adequately qualified and committed radiologist, gynecologic oncologist, and pathologist. All institutions had study-specific institutional review board (IRB) approval. Between March 2000 and November 2002, 208 participants were accrued from 25 academic and community health centers. Methodology is described in further detail in earlier publications
Results
A more detailed description of this patient cohort and multiobserver analysis is described in prior publications [18], [19], [20], and summarized in Appendix 1. Surgical and pathological tumor characteristics are summarized in Table 1. A representative case is illustrated in Fig. 1.
Comment
Most evaluations of cross-sectional imaging have assessed its accuracy compared with a pathologic reference standard. However, the radical surgical specimen is not available for preoperative clinical decision making, and the pathological findings are far from perfect in predicting clinical outcome [2], [4], [6]. It is therefore important to study diagnostic methods that can be utilized prior to and during clinical treatment, and to verify these methods based on clinical outcome whenever
Conflict of interest statement
The authors have no conflicts of interest to declare.
Acknowledgments
This study was funded by NCI grant # U01 CA079778 and U01 CA080098 and was conducted jointly by the American College of Radiology Imaging Network (ACRIN) and the Gynecologic Oncology Group (GOG). Data were collected, managed and analyzed by the Biostatistics and Data Management Center of ACRIN. Both ACRIN and GOG participated in the study design, the data analysis, the writing of the report, and the decision to submit the paper for publication. The NCI did not participate in the study design,
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