Developmental cytologyDNA synthesis and differentiation in developing white adipose tissue☆
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Adipose tissue plasticity from WAT to BAT and in between
2014, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :AT development is initiated during the second trimester in humans [23,24,29], and during the perinatal period in rodents [27,31]. Subcutaneous AT generally develops before abdominal adipose tissue in rodents [26,27] and humans [32]. Overall, differentiation progresses in an anterior to posterior, rostral to caudal, and dorsal to ventral direction in various species, including man [25,28].
Accurate detection of metabolically active "brown" and "white" adipose tissues with computed tomography
2013, Academic RadiologyCitation Excerpt :BAT is inversely associated with obesity and metabolic disease (19). Brown fat cells could derive from direct conversion of white adipocytes (20,21), which have been proved to effectively prevent obesity, facilitate weight reduction, increase the systemic glucose clearance, and ameliorate insulin resistance (22). FDG PET has been extensively used to trace tumor metastasis.
In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding
2012, Cell MetabolismCitation Excerpt :Unexpectedly, a terminal adipocyte differentiation marker, Perilipin1 (PLIN1), was also expressed in numerous EdU flash-labeled (i.e., 2 hr exposure) cells, especially after 3 days of CL treatment. EdU+ adipocytes were small (<10 μm) and contained small lipid droplets, indicating that newly differentiating adipocytes can divide (Pilgrim, 1971). ( We have not observed cell division in mature, unilocular adipocytes.)
The roles of PPARs in adipocyte differentiation
2001, Progress in Lipid ResearchIn developing brown adipose tissue c-myc protooncogene expression is restricted to early differentiation stages
1989, Cell Differentiation and DevelopmentAdipose conversion of Ob17 preadipocytes. Relationships between cell division and fat cell cluster formation
1982, Experimental Cell Research
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Supported by the Deutsche Forschungsgemeinschaft.
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Present address: Department of Morphology and Anatomy, University of Regensburg, 84 Regensburg, Germany.