Benzene and leukemia
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Cited by (116)
A clandestine culprit with critical consequences: Benzene and acute myeloid leukemia
2021, Blood ReviewsCitation Excerpt :These early studies, however, were limited by imprecise exposure assessment methods prone to measurement error and exposure misclassification. Occupational studies from the 1970s-1980s with expert-based, historical quantitative exposure assessments observed an increased risk of AML with cumulative benzene exposure in the range of 100 or 200 ppm-years [34–38]. In 1987 the International Agency for Research on Cancer (IARC) concluded that there was sufficient evidence of increased incidence of acute nonlymphocytic leukemia (ANLL, a synonym for AML) among workers with occupational exposure to conclude that benzene causes AML/ANLL [39].
Unbalanced metabolism of endogenous estrogens in the etiology and prevention of human cancer
2011, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :The recognition that benzene is a human leukemogen required evaluation of large populations exposed to the chemical [1]. These data were obtained from Italian and Turkish workers in the shoemaking and printing industries, who had high incidences of acute myeloid leukemia [2]. More recently, the induction of non-Hodgkin lymphoma by benzene has been demonstrated [3,4].
Hematopoietic neoplastic diseases develop in C3H/He and C57BL/6 mice after benzene exposure: Strain differences in bone marrow tissue responses observed using microarrays
2010, Chemico-Biological InteractionsCitation Excerpt :The three major questions regarding benzene-induced hematopoietic neoplasms (HPNs) addressed are as follows: first, why is the incidence of HPNs equivocal in the case of low-dose benzene exposure despite the significant genotoxicity of benzene even at low doses [4]; second, why is there a plateau-like ceiling in the increase in the incidence of HPNs following high-dose exposure despite a low acute toxicity [5]? Third, why are acute myeloid leukemias (AMLs) not commonly observed in mice following benzene exposure even though they are frequently observed in humans after occupational benzene exposure [6–8]? Since C3H/He mice are known to be AML-prone and to produce AMLs following radiation exposure [9,10], and C57BL/6 mice are known to be lymphoma-prone [11–13], these two strains were used for comparison.