Expression of constitutive endothelial nitric oxide synthase in human blood platelets
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Alterations in endothelial nitric oxide synthase activity and their relevance to blood pressure
2022, Biochemical PharmacologyCitation Excerpt :Endothelial specific eNOS-KO Several laboratories including our group reported the role of non-endothelial eNOS in blood pressure homeostasis [192–194]. Non-endothelial eNOS expression was suggested in circulating blood cells including leucocytes[195], platelets [196] and RBCs [194], in the kidney [192] and in astrocytes of the brain stem[197]. The relative importance of endothelium-derived NO for the regulation of blood pressure was questioned in a study in which the bovine eNOS was endothelium-specifically re-expressed in the eNOS-KO mice [193].
The effects of gasotransmitters on bronchopulmonary dysplasia
2020, European Journal of PharmacologyNitric oxide-enhancing or -releasing agents as antithrombotic drugs
2019, Biochemical PharmacologyCitation Excerpt :cGMP, in turn, activates cGMP-dependent protein kinase G which phosphorylates several intracellular proteins which lower cytoplasmic calcium, favouring its reuptake by intracellular stores, its extrusion and inhibiting its influx, thus turning-off cell activation. Besides the endothelium, which probably generates the largest amount of NO in the circulation, also leukocytes, red blood cells and platelets express eNOS and iNOS [13–16]. eNOS-derived NO plays a pivotal role in the control of vascular tone and in the prevention of thrombosis and atherosclerosis [17], with differential roles played by the various cells.
Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseases
2017, Nitric Oxide - Biology and ChemistryCitation Excerpt :Altogether, these findings highlight the idea that accumulated nitrite correspond to an important NO reservoir. Although NOS3 was firstly described in endothelial cells [44,45], it is expressed in non-endothelial cell types including platelets [46], cardiomyocytes [47], and neurons [48]. In this regard, NOS3 expression and activity are regulated by transcriptional, posttranscriptional, and posttranslational mechanisms.
NOS, NO, and the Red Cell
2017, Nitric Oxide: Biology and Pathobiology: Third Edition