Toxicology of trichloroethylene in the mouse

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Abstract

The purpose of this study was to evaluate the acute and subchronic toxicology of trichloroethylene (TCE) in the mouse. The oral LD50 in female mice was 2443 mg/kg (95% confidence limits of 1839–3779 mg/kg) and in male mice was 2402 mg/kg (95% confidence limits of 2065–2771 mg/kg). After determination of the LD50 by the oral route, a 14-day study was done in male CD-1 mice in which TCE was administered daily by gavage at 24 and 240 mg/kg. A subchronic drinking water study was designed based on these data, in which TCE at concentrations of 0.1, 1.0, 2.5, and 5.0 mg/ml was used, and mice of both sexes were exposed for 4 or 6 months. There was a decreased body weight gain at the highest dose, which could be attributed to a decrease in fluid consumption. The most significant effects attributable to TCE were an increase in liver weight in both sexes accompanied by increased nonprotein sulfhydryl levels in the males, and an increase in kidney weight in both sexes accompanied by increases in protein and ketones in the urine. TCE failed to elicit any other adverse effects.

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Due to the volume of negative data generated in these studies, this article summarizes only the positive results. Persons interested in obtaining the complete data from which the conclusion of this paper were drawn should contact Dr. A. E. Munson at the Department of Pharmacology, Medical College of Virginia. This work was supported by the U.S. Army Medical Research and Development Command (DAMD 17-78-C-8083) and the Environmental Protection Agency (R806481010).

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