Distribution and actions of galanin and vasoactive intestinal peptide in the human colon

doi:10.1016/0143-4179(90)90115-F

Neuropeptides

Volume 16, Issue 2, June 1990, Pages 77-82

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Abstract

Responses to galanin (GAL) and vasoactive intestinal peptide (VIP) and their distribution were investigated in muscularis externa from the human sigmoid colon. Immunohistochemical studies revealed GAL-like immunoreactivity (GAL-IR) and VIP-IR in nerve fibres supplying both muscle layers as well as the myenteric ganglia. Additionally GAL-IR was shown to co-exist with VIP-IR in many nerve fibres innervating human circular and longitudinal (taenial) colonic muscle layers. Circular and longitudinal muscle strips were contracted by GAL and relaxed by VIP. There was a marked difference in sensitivity between muscle layers to both peptides; circular muscle being less sensitive to GAL, longitudinal muscle less sensistive to VIP. When given simultaneously GAL attenuated responses to VIP on longitudinal muscle, thus in the same neurone there are substances having opposing actions on smooth muscle motility.

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Distribution and actions of galanin and vasoactive intestinal peptide in the human colon

Abstract

FEBS Lett.

Life Sci.

Gastroenterology

Neurosci. Lett.

Gastroenterology

Eur. J. Pharmacol.

Galanin: a newly isolated biologically active neuropeptide

TINS

Distribution of galanin-like immunoreactivity in the gastrointestinal tract of several mammalian species

Cell. Tiss. Res.

Galanin immunoreactive neurones in the guinea-pig small intestine: their projections and relationships to other enteric neurones

Cell & Tiss. Res.