Hepatic and renal blood flow responses to a clinical dose of intravenous cyclosporine in the pig
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Cited by (8)
Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow
2011, Life SciencesCitation Excerpt :Most of the studies on this field have examined the CsA- or ET-1-induced changes in rat isolated hepatocyte perfusion or on biochemical measures. The change in the hepatic artery flow in response to CsA administration has also been studied (Andreoni et al. 1994). The present in vivo study aimed to examine the acute effect of CsA on LHBF which is a direct indicator of local liver perfusion, and to correlate the hemodynamic changes with biochemical and histopathological measures in guinea pigs.
Pharmacokinetic characterization of a pig model of ciclosporin A nephrotoxicity following intravenous administration
2007, Pharmacological ResearchThe pharmacokinetics and acute renal effects of oral microemulsion ciclosporin A in normal pigs
2006, International ImmunopharmacologyCitation Excerpt :In the CsA 30 mg group RBF was expected to be higher because of the weight gain and increase in blood flow [17], and our results indicate therefore also an acute reduction in this functional parameter by CsA 30 mg/kg, whereas no change in RBF was seen with CsA 15 mg/kg. RBF response to CsA in pigs has previously been investigated by Calvert and Terris [18] and Andreoni et al. [19]. Calvert et al. were unable to demonstrate any significant changes in RBF in response to CsA.
Plasma concentration of hGH and anti-hGH antibodies after subcutaneous administration of hGH for 3 weeks to immunosuppressed pigs
1999, Journal of Pharmacological and Toxicological MethodsEffect of dihydropyridine calcium channel blockers and glucocorticoids on the prevention and development of scleroderma renal crisis in an Italian case series
2013, Clinical and Experimental RheumatologyPost-conditioning with cyclosporine A fails to reduce the infarct size in an in vivo porcine model
2010, Acta Anaesthesiologica Scandinavica