Structure-activity relationships in the rat hepatocyte DNA-repair test for 300 chemicals
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DNA-damaging activities of twenty-four structurally diverse unsubstituted and substituted cyclic compounds in embryo-fetal chicken livers
2019, Mutation Research - Genetic Toxicology and Environmental MutagenesisCitation Excerpt :2,6-Xylidine was carcinogenic in a chronic bioassay in rats, inducing adenomas and carcinomas of the nasal cavity in both sexes [51]. Interestingly, while 2,5-xylidine was positive in the rat hepatocyte DNA repair assay, o-toluidine did not induce DNA repair, perhaps, because of slow repair [15]. Based on the sufficient evidence for o-toluidine carcinogenicity for urinary-bladder in experimental animals and humans with occupational exposures, it was evaluated as “known to be a human carcinogen” (Group 1) by International Agency for Research on Cancer [18].
Review of the evidence for thresholds for DNA-Reactive and epigenetic experimental chemical carcinogens
2019, Chemico-Biological InteractionsIn vivo comet assay of acrylonitrile, 9-aminoacridine hydrochloride monohydrate and ethanol in rats
2015, Mutation Research - Genetic Toxicology and Environmental MutagenesisGenotoxicity and carcinogenicity testing of pharmaceuticals: Correlations between induction of DNA lesions and carcinogenic activity
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