Induction of chromosome damage in mouse bone marrow by benzo[a]pyrene
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Evaluation of the RBC Pig-a assay and the PIGRET assay using benzo[a]pyrene in rats
2016, Mutation Research - Genetic Toxicology and Environmental MutagenesisCitation Excerpt :It also induced gene mutations in V79 cells [20], Chinese hamster ovary cells [13], and mouse lymphoma L5178Y TK (+/−) cells but only after metabolic activation [21]. In in vivo assays, positive results for BP genotoxicity were obtained in a micronucleus test in mice [14] and in a gene mutation assay in transgenic mice [22]. In addition, the in vivo mutagenicity of BP was detected using the RBC Pig-a assay in gpt delta C57BL/6J transgenic mice [10] and in rats [11].
Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review
2016, Mutation Research - Reviews in Mutation ResearchCitation Excerpt :BaP can be metabolized to four different diolepoxides, all of which are DNA-reactive. Chromosomal aberrations, DNA damage (by comet assay), sister chromatid exchange, DNA adducts, micronuclei and mutations have all been reported in rodents and/or humans exposed to BaP [35–38]. Most of the mechanistic data for BaP has been conducted in experimental mammals, showing that it is a multi-tissue carcinogen that primarily induces carcinomas of the lung, skin, liver, forestomach and mammary gland.
Wildlife Toxicity Assessment for Benzo[a]Pyrene
2015, Wildlife Toxicity Assessments for Chemicals of Military ConcernThe use of immunomagnetic separation of erythrocytes in the in vivo flow cytometer-based micronucleus assay
2013, Mutation Research - Genetic Toxicology and Environmental MutagenesisAssessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene in C57BL/6J mice
2011, Food and Chemical ToxicologyCitation Excerpt :On the other hand, it was the lowest dose, that enabled the detection of protective effects from the selected putative chemopreventive agents with respect to DNA adduct formation. Besides, this dose closely matches previously obtained data for the mouse bone marrow MN assay, indicating 25 mg B[a]P/kg to represent the lowest effective dose level (Kliesch et al., 1982). An intriguing observation in the present study was the effect of GT on water consumption and body weight.
Anti-clastogenic effect of magnolol on benzo(a)pyrene-induced clastogenicity in mice
2008, Food and Chemical Toxicology