Genotoxicity of aloeemodin in vitro and in vivo
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Cited by (60)
The absence of genotoxicity of Aloe vera beverages: A review of the literature
2023, Food and Chemical ToxicologyHerbal Remedies
2023, Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 3: Environmental Toxicologic Pathology and Major Toxicant ClassesLack of genotoxicity of rhubarb (rhizome) in the Ames and micronucleus in vitro tests
2022, Toxicology ReportsAloe-emodin, a hydroxyanthracene derivative, is not genotoxic in an in vivo comet test
2021, Regulatory Toxicology and PharmacologyCitation Excerpt :Since hydroxyanthracene derivatives, such as aloe-emodin, are essential components of many herbal preparations, based on the possible harmful effect on health identified by the EFSA, the European Commission decided to place aloe-emodin and all the extracts in which this substance is present in Part A (ban on the use in food) of Annex III of Regulation (EC) no. 1925/2006 of the European Parliament and of the Council to ensure a high level of health protection in accordance with the precautionary principle provided for in Article 7 of Regulation (EC) 178/2002 (Commission Regulation (EU) 2021/468 of March 18, 2021). Most of the experiments conducted with aloe-emodin in vitro with bacteria and mammalian cells have shown a genotoxic effect (Chen et al., 2010; Heidemann et al., 1996; Mueller and Stopper, 1999), with a reduction of the amount of monomer DNA generated by topoisomerase II, indicating that the compound is capable of inhibiting topoisomerase II-mediated decatenation. On the other hand, most of the in vivo genotoxicity experiments, in which animals received doses up to 2000 mg/kg bw, showed negative results, even if the data were considered by the ANS Panel to be insufficiently reliable since a validated protocol was not strictly followed (Heidemann et al., 1993, 1996; Mengs et al., 1997).
A competitive nature-derived multilayered scaffold based on chitosan and alginate, for full-thickness wound healing
2021, Carbohydrate PolymersCitation Excerpt :It has been demonstrated that emodin (identified compound 8 in Fig. S1) as one of the anthraquinones derivatives plays an important role in tissue regeneration induced by AV (Jia, Zhao, & Jia, 2008). Even though there are a few reports showed that the oral administration of emodin could be carcinogenic in rats (Guo & Mei, 2016; Heidemann, Völkner, & Mengs, 1996; Program, 2001), a study by Lin et al. indicated in vitro and in vivo anticancer activity of emodin on pancreatic cancer cells via NF-κB inhibition (Lin et al., 2012). More studies are warranted to investigate the possible toxicity of emdoin.
Role of anthraquinones in Cassia occidentalis induced hepato-myo-encephalopathy
2021, Journal of EthnopharmacologyCitation Excerpt :These investigations reveal that CO seeds could mediate their toxicity in male and female animals via different mechanisms, which needs to be elaborated further through systematic studies for developing a better understanding of toxicity mechanism of CO and devising appropriate gender specific treatment regimen. Aloe-emodin, another AQ, which bears close structural similarity with emodin, showed structural chromosomal aberrations in CHO (Heidemann et al., 1996) and L5178Y mouse-lymphoma cells (Müller et al., 1996). Through an in-vitro unscheduled DNA synthesis (UDS) test, it was found that treatment of aloe-emodin to rat hepatocytes causes primary DNA damage (Westendorf et al., 1990).