Spermatid micronucleus analyses of trichloroethylene and chloral hydrate effects in mice
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Cited by (38)
Assessing the genotoxicity of two commonly occurring byproducts of water disinfection: Chloral hydrate and bromal hydrate
2017, Mutation Research - Genetic Toxicology and Environmental MutagenesisCitation Excerpt :CH was also found to induce significant aneugenic effects in mice [41]. Furthermore, micronuclei were produced in germ cells of male mice treated intraperitoneally with CH [42]. CH was also reported to be able to lead to chromosomal loss in mouse spermatids [43] and in human lymphocytes [44].
Mutagenic analysis of six disinfection by-products in the Tk gene of mouse lymphoma cells
2011, Journal of Hazardous MaterialsCitation Excerpt :It must be emphasized the importance that the current regulations give to toxicity, to avoid false positive data due to over stressed cell [22]. Previous published results have shown that this chlorinated HA is a direct-acting mutagen that induces point mutations, increases the frequency of MN in mouse spermatocytes and cultured human fibroblasts, increases the induction of primary DNA damage in TK6 cells, and induces MN and SCE in peripheral blood lymphocytes of treated children [34,39–43]. By the contrary, negative results were obtained in cultured CHO cells (comet assay) and in TK6 cells (MN test) [34,44].
DNA damage induction by two halogenated acetaldehydes, byproducts of water disinfection
2010, Water ResearchCitation Excerpt :In terms of cytogenetic assessment, a number of studies reporting positives and negatives are described in the literature. CH was able to increase the frequency of MN in mouse spermatocytes (Russo and Levis, 1992), as well as MN and chromosome loss in germ cells of male mice (Allen et al., 1994; Nutley et al., 1996). In addition, significant increases in the frequencies of MN and SCE in blood peripheral lymphocytes have reported in infants treated with CH (Ikbal et al., 2004).
In vivo erythrocyte micronucleus assay. III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test
2007, Mutation Research - Genetic Toxicology and Environmental MutagenesisThe assessment of genotoxic effects in lymphocyte cultures of infants treated with chloral hydrate
2004, Mutation Research - Genetic Toxicology and Environmental MutagenesisMetabolism and toxicity of trichloroethylene in epididymis and testis
2002, Toxicology and Applied Pharmacology