Elsevier

Lung Cancer

Volume 11, Issues 3–4, September 1994, Pages 179-190
Lung Cancer

Original article
Risk factors for lung cancer in Rio de Janeiro, Brazil: a case-control study

https://doi.org/10.1016/0169-5002(94)90538-XGet rights and content

Abstract

The association between the risk of lung cancer and tobacco smoking, dietary factors and occupational exposures was examined in a hospital-based case-control study. The study involved 123 consecutive cases and 123 controls, matched by age (± 3), sex, and race. In this first study of lung cancer risk in Brazil, we found that tobacco smoking is the strongest risk factor with an odds ratio (OR) for current and former smokers of 22 (C1, 6.5–76) and 7.7 (CI, 2.2–27), respectively. An OR of 2.8 (CI, 1.0–7.7) was found for users of black tobacco (in the form of hand-rolled cigarettes) in combination with conventional cigarettes, after adjustment for life-time consumption of any kind of tobacco; users of conventional cigarettes only were considered as a reference group. Cessation of smoking had an important influence in reducing the lung cancer risk, whereas early initiation of smoking increased the risk. Among dietary factors, frequent consumption of meat (P < 0.01) and pasta (P = 0.02) were positively associated with lung cancer risk after adjusting for smoking and income. No association was found with green/yellow vegetables or fruits. We were unable to detect any significant association related to occupational exposures. This study confirmed the association of lung cancer with smoking as the most important predictor of risk. It also indicates the increase in risk associated with the use of black tobacco in combination with conventional cigarettes.

References (28)

  • J.M. Bishop

    Molecular themes in oncology

    Cell

    (1991)
  • K Kawajiri et al.

    Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene

    FEBS

    (1990)
  • N.E. Breslow et al.

    Statistical methods in cancer research. Vol. I

  • R.C. Brownson et al.

    Risk factors for adenocarcinoma of the lung

    Am J Epidemiol

    (1987)
  • N.E. Caporaso et al.

    Lung cancer and debrisoquine metabolic phenotype

    J Natl Cancer Inst

    (1990)
  • V.L. Costa e Silva et al.

    Epidemiologia do tabagismo no Brasil [in Portuguese]

    J Bras Med

    (1991)
  • E De Stefani et al.

    Type of tobacco and risk of lung cancer: a case-control-study from Uruguay

    Lung Cancer

    (1992)
  • R Doll et al.

    The significance of cell type in relation to the aetiology of lung cancer

    Br J Cancer

    (1957)
  • R Doll et al.

    Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers

    J Epidemiol Community Health

    (1978)
  • S Franceschi et al.

    Nutrition and cancer of the oral cavity and pharynx in North-east Italy

    Int J Cancer

    (1991)
  • E.L. Franco et al.

    Risk factors for oral cancer in Brazil

    Int J Cancer

    (1989)
  • M.T. Goodman et al.

    The effect of dietary cholesterol and fat on the risk of lung cancer in Hawaii

    Am J Epidemiol

    (1988)
  • M.W. Hinds et al.

    Dietary vitamin A, carotene, vitamin C, and risk of lung cancer in Hawaii

    Am J Epidemiol

    (1984)
  • T Hirayama

    Diet and cancer

    Nutr Cancer

    (1979)
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