Elsevier

Toxicology

Volume 35, Issue 2, May 1985, Pages 143-160
Toxicology

Lung injury induced by trichloroethylene

https://doi.org/10.1016/0300-483X(85)90028-9Get rights and content

Abstract

Trichloroethylene (TCE) produced bronchiolar damage when administered to mice. Administration of 2000 mg/kg caused injury in Clara cells of the bronchiolar epithelium, which was observed at 24 h following TCE treatmwnt; increase of the dosage to 2500 mg/kg induced additionally, alterations in alveolar Type II cells of the parenchyma. Specifically, lamellar bodies were reduced in number and microvilli displayed distorted protrusions. The increase in severity of cellular injury with higher dosages of TCE coincided with increased accunulation of pulmonary calcium and lengthened anesthesia recovery times following TCE-induced anesthesia. Time-course studies conducted with 2000 mg/kg demonstrated rapid and marked reduction in pulmonary microsomal cytochrome P-450 content and aryl hydrocarbon hydroxylase activity. Significant decreases were observed as early as 1 h, and the levels were still depressed at 24 h following TCE treatment. Hepatic necrosis was relatively mild at the dosages of TCE examined. These results demonstrate that TCE is pneumotoxic and affects Clara and alveolar Type II cells.

References (51)

  • M. Ikeda et al.

    Metabolism of trichloroethylene

    Biochem. Pharmacol.

    (1980)
  • D. Pessayre et al.

    Inhibition, activation, destruction and induction of drug-metabolizing enzymes by trichloroethylene

    Toxicol. Appl. Pharmacol.

    (1979)
  • K.R. Krijgsheld et al.

    Lung-selective impairment of cytochrome P-450 dependent monooxygenases and cellular injury by 1,1-dichloroethylene in mice

    Biochem. Biophys. Res. Commun.

    (1983)
  • K.R. Krijgsheld et al.

    Selective damage to nonciliated bronchiolar epithelial cells in relation to impairment of pulmonary monooxygenase activities by 1,1-dichloroethylene

    Toxicol. Appl. Pharmacol.

    (1984)
  • G.D. Lewis et al.

    Some effects of trichloroethylene on mouse lungs and liver

    Gen. Pharmacol.

    (1984)
  • R.J. Defalque

    Pharmacology and toxicology of trichloroethylene. A critical review of the world literature

    Clin. Pharmacol. Ther.

    (1961)
  • S.K. Sharpless
  • G. Ziglio

    Human exposure to environmental trichloroethylene and tetrachloroethylene: Preliminary data on population groups of Milan, Italy

    Bull. Environ. Contam. Toxicol.

    (1981)
  • G. McConnell et al.

    Chlorinated hydrocarbons and the environment

    Endeavor

    (1975)
  • B.L. Van Duuren

    Chemical structure, reactivity and carcinogenicity of halohydrocarbons

    Environ. Health Perspect.

    (1977)
  • National Cancer Institute Report. Carcinogenesis bioassay of trichloroethylene. Carcinogenesis Technical Report Series,...
  • G.F. Smith

    Trichloroethylene: A review

    Br. J. Ind. Med.

    (1966)
  • H.H. Cornish et al.

    Ethanol potentiation of halogenated aliphatic solvent toxicity

    Am. Ind. Hyg. Assoc., J.

    (1966)
  • G.P. Carlson

    Enhancement of the hepatotoxicity of trichloroethylene by inducers of drug metabolism

    Res. Commun. Chem. Pathol. Pharmacol.

    (1974)
  • H.M. Bolt et al.

    Irreversible binding of chlorinated ethylenes to macro-molecules

    Environ. Health Perspect.

    (1977)
  • Cited by (0)

    View full text