Biological monitoring for mutagenic effects of occupational exposure to butadiene
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Cited by (64)
Utilization of bio-polymeric additives for a sustainable production strategy in pulp and paper manufacturing: A comprehensive review
2021, Carbohydrate Polymer Technologies and ApplicationsThe ex vivo L-CBMN assay detects significant human exposure to butadiene
2016, Mutation Research - Reviews in Mutation ResearchCitation Excerpt :Mutation frequency at hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus has been investigated in BD-exposed workers with conflicting results. Studies carried out in Texas [27–32] on workers from synthetic rubber manufacturing plants, using as raw materials polymerized polybutadiene rubber and styrene-butadiene copolymers, have reported significantly elevated frequencies of HPRT gene mutations in peripheral blood lymphocytes with the exception of the most recent one [33], where the large majority of exposures were below the detection limit of the method and did not show any increase of the frequency of mutant lymphocytes. In other studies BD exposed workers did not reveal increased levels of somatic mutations measured by HPRT and by Glycophorin A (GPA) mutation frequency [21,23,34,35].
Genotoxic risk in rubber manufacturing industry: A systematic review
2014, Toxicology LettersHemoglobin adducts in 1,3-butadiene exposed Czech workers: Female-male comparisons
2010, Chemico-Biological InteractionsCitation Excerpt :Molecular epidemiological studies in humans can provide information analogous to that derived from animal studies by using biomarkers to assess metabolism and measure internal doses of exogenous agents, identify differential susceptibilities to these agents, and determine pre-cancer effects such as mutagenicity. There have been several such studies of BD-exposed workers [24–41]. One of the most recent studied both female (n = 49) and male (n = 55) workers in the elastomer and latex units of a BD polymerization facility in the Czech Republic with the goal of identifying sex differences in biomarker responses in BD-exposed humans [41].
Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene
2007, Chemico-Biological InteractionsCitation Excerpt :Epidemiological studies examining human sensitivity to 1,3-butadiene (BD) following occupational exposures have found an association between somatic mutations and exposure [1–8], while other studies have not found such an association [9–12].
Biomarkers in risk assessment of asbestos exposure
2005, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis