Cancer Letters

Cancer Letters

Volume 28, Issue 1, August 1985, Pages 85-92
Cancer Letters

Research letter
In vitro transformation of BALBc-3T3 cells by chlorinated ethanes and ethylenes

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Abstract

Eight chlorinated ethanes and 3 chlorinated ethylenes were tested in the BALBc-3T3 cell transformation assay. Under the conditions of the assay, vinyl chloride and 1,1,1-trichloroethane induced a clear positive transformation response while 1,1,2-trichloroethane and trichloroethylene were weakly positive. Chloroethane, 1,1- and 1,2-dichloroethane, 1,1,1,2- and 1,1,2,2-tetrachloroethane, hexachloroethane and tetrachloroethylene were all negative in the assay conducted in the absence of an exogenous metabolic activation system. These results suggest that the BALBc-3T3 cells possess capability to activate some, but not all, of the chlorinated hydrocarbons which exhibit species specificity in producing carcinogenicity in mice but not in rats.

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