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Alcohol-induced hepatic sinusoidal endothelial cell dysfunction in the mouse is mediated by Kupffer cells

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Abstract

Significant increase in plasma hyaluronan level (104%) and a marked inhibition of hyaluronan uptake by the isolated, perfused liver (54%) were seen 3 h after intraperitoneal administration of alcohol (4.4 g/kg body wt.) to mice. Intravenous administration of GdCl3 (10 mg/kg body wt.), an agent that inactivates/eliminates Kupffer cells, 24 h prior to alcohol administration, counteracted the alcohol-induced suppression of hepatic hyaluronan uptake and diminished the alcohol effect on plasma hyaluronan concentration. These data suggest that alcohol-induced impairment of the hepatic sinusoidal endothelial cell function is mediated by Kupffer cells.

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