2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis
A series of substituted 2,4,5-triarylimidazole derivatives were prepared and evaluated as inhibitors of IL-1 and 5-lipoxygenase biosynthesis.
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The danger of dichloromethane in the synthesis and application of imidazole-based dyes
2022, Dyes and PigmentsCitation Excerpt :Imidazole possessing a typical asymmetric five-member heterocyclic ring has been widely used as key compound for the synthesis of various drugs [1–4] and organometallic complexes [5–8].
Core-shell zirconia-coated magnetic nanoparticles offering a strong option to prepare a novel and magnetized heteropolyacid based heterogeneous nanocatalyst for three- and four-component reactions
2020, Arabian Journal of ChemistryCitation Excerpt :Hence, it is used in many organic transformations, such as dehydration, esterification, acylation, and oxidation (Mallik et al., 2006). On the other hand, there have been no reports on the preparation of phosphomolybdic acid (H3PMO12O40) supported on nano-Fe3O4@ZrO2 and using it as a catalyst for the synthesis of biological, therapeutical and agricultural useful multisubstituted imidazoles (Antolini et al., 1999; Bossche et al., 1983; Deprez et al., 2002; Freedman and Loscalzo, 2009; Gallagher et al., 1995; Lange et al., 2005; Laszlo et al., 1999; Sarshar et al., 2000; Wang et al., 2002). Such a magnetically acid nanocatalyst displayed extraordinary catalytic performance in the multicomponent reaction for the one-pot synthesis of 2, 4, 5-trisubstituted imidazoles from the reaction of aromatic aldehydes, benzil and NH4OAc as well as for the preparation of 1, 2, 4, 5-tetrasubstituted imidazoles from the condensation of aromatic aldehydes, amines, benzil, and NH4OAc under solvent-free conditions.
Synthesis and characterization of amino glucose-functionalized silica-coated NiFe<inf>2</inf>O<inf>4</inf> nanoparticles: A heterogeneous, new and magnetically separable catalyst for the solvent-free synthesis of 2,4,5–trisubstituted imidazoles, benzo[d]imidazoles, benzo[d] oxazoles and azo-linked benzo[d]oxazoles
2018, Journal of Organometallic ChemistrySynthesis and XRD, FT-IR vibrational, UV–vis, and nonlinear optical exploration of novel tetra substituted imidazole derivatives: A synergistic experimental-computational analysis
2018, Journal of Physics and Chemistry of SolidsCitation Excerpt :Tetra substituted imidazoles are very important heterocyclic compounds in pharmaceutical and biochemical processes [2], and are biologically active compounds having fungicidal [3], anti-inflammatory [4], analgesic [5], antitumor [6] and antibacterial activities [7]. Members of this class also act as inhibitors of p38 mitogen-activated protein kinase [8], B-Raf kinase [9], transforming growth factor β1 receptor type 1 [10], biosynthesis of interleukin-1 [11], and cyclooxygenase-2 [12]. Substituted imidazoles are widely used as glucagon receptors [13], CB1 cannabinoid receptor antagonists [14] and modulators of P-glycoprotein mediated multidrug resistance agents [15].
Synthesis of 2,4,5-triarylated imidazoles via three-component domino reaction under catalyst-free conditions
2017, Journal of Saudi Chemical Society