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A pathological study on the toxicity of S-dichlorovinyl-l-cysteineEtude pathologique sur la toxicité de la S-dichlorovinyl-l-cystéineEine pathologische studie über die toxizität von S-dichlorvinyl-l-cystein

https://doi.org/10.1016/S0015-6264(65)80010-4Get rights and content

Abstract

The acute toxicity of S-dichlorovinyl-l-cysteine (DCVC) has been studied in several species of laboratory animals, in a dog and in a cat. No bone marrow changes have been observed. In all the species tubular necrosis of the kidneys was obvious. Pancreatic changes have been observed in rats and mice. A few rats showed perilobular necrosis in the liver. In a subacute experiment on rats, DCVC was given in the drinking water for 12 weeks. A few animals showed liver changes including marked bile duct proliferation whilst in the others no liver damage was detected histologically. In all the rats characteristic enlarged nuclei were observed in the epithelium of the proximal convoluted tubules of the kidneys.

Résumé

L'intoxication aiguë par la S-dichlorovinyl-cystéine (DCVC) a été étudiée sur différentes espèces d'animaux de laboratoire, sur un chien et sur un chat. On n'observa aucune modification de la moëlle osseuse. Dans toutes les espèces, la nécrose des tubes rénaux était évidente. Des modifications au niveau du pancréas ont été observées chez des rats et des souris. Quelques rats présentèrent de la nécrose péri-lobulaire du foie.

Dans une expérience sur l'intoxication subaiguë chez des rats, la DCVC fut donnée dans l'eau de boisson pendant 12 semaines. Quelques animaux présentèrent des modifications au niveau du foie, parmi lesquelles une prolifération marquée des canaux biliaires, tandis que chez d'autres aucune atteinte hépatique ne fut décelable histologiquement. Chez tous les rats on observa une augmentation de volume caractéristique des noyaux cellulaires au niveau de l'épithélium de la partie proximale des tubes contournés du rein.

Zusammenfassung

Die akute Toxizität von S-Dichlorvinyl-l-cystein (DCVC) wurde an verschiedenen Labortierarten, am Hund und an der Katze, untersucht. Am Knochenmark wurden keine Veränderungen beobachtet. Bei allen Tieren traten Nekrosen der Nierentubuli auf. Bei Ratten und Mäusen wurden Veränderungen der Bauchspeicheldrüse festgestellt. Einige Ratten wiesen perilobuläre Nekrosen in der Leber auf. In einem subakuten Versuch erhielten Ratten 12 Wochen DCVC im Trinkwasser. Einige Tiere wiesen Leberveränderungen einschliesslich deutlicher Gallengangswucherungen auf, während bei anderen Tieren histologisch keine Leberschäden festzustellen waren. Alle Ratten zeigten charakteristisch vergrösserte Zellkerne des Epithels der proximalen Tubulusabschnitte der Nieren.

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    Present address: Istituto di Anatomia e Istologia Patologica, Università, Torino, Italy.

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