Research sectionA pathological study on the toxicity of S-dichlorovinyl-l-cysteineEtude pathologique sur la toxicité de la S-dichlorovinyl-l-cystéineEine pathologische studie über die toxizität von S-dichlorvinyl-l-cystein
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Cited by (93)
Advances in TCE Toxicology
2017, Advances in Molecular ToxicologyCitation Excerpt :In particular, DCVC can also induce DNA strand breaks and micronucleus formation in primary kidney cells from rats and humans [18]. Additionally, the histological changes in renal proximal tubular cells of rats exposed to DCVC are quite similar to those reported in TCE studies [19]. A number of investigations have studied the effect of polymorphisms of the glutathione-S-transferase (GST) metabolic pathway on kidney cancer and TCE exposure [20–22].
Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene
2013, Toxicology and Applied PharmacologyCitation Excerpt :Cytomegaly, karyomegaly, and toxic nephrosis of tubular epithelial cells in the cortico-medullary junction are observed in rats that are chronically exposed to TCE (Lash et al., 2000; Lock and Reed, 2006). DCVC is known to cause necrosis in the proximal tubules of the inner cortex (i.e. the S3 segment of the proximal tubule) while leaving the medulla spared (Lash et al., 1994; Terracini and Parker, 1965). Interestingly, treatment of rats with an equimolar dose of DCVC to the one used in the present study (230 μmol/kg b.w.) resulted in scattered, patchy foci of tubular necrosis (Lash et al., 1994).
Putting bioactivation reactions to work: Targeting antioxidants to mitochondria
2011, Chemico-Biological InteractionsCitation Excerpt :These studies were extended to include a series of ω-fluoroalkanoates [32], which showed that ω-fluoroalkanoates with an odd number of carbons are toxic and that the toxicity mimicks that caused by fluoroacetate itself, whereas ω-fluoroalkanoates with an even number of carbons are not toxic (Fig. 2). Parker [33] investigated the role of the amino group in S-(1,2-dichlorovinyl)-l-cysteine (DCVC)-induced mitochondrial toxicity. The desamino analog 5,6-dichloro-4-thia-5-hexenoate (DCTH) was highly toxic, whereas removal of the carboxylic acid group gave 2-[(1,2-dichlorovinyl)thio]ethylamine, which was not toxic (Fig. 3).
Halogenated Hydrocarbons
2010, Comprehensive Toxicology, Second EditionThe use of mechanistic data and the handling of scientific uncertainty in carcinogen risk assessments
2002, Regulatory Toxicology and PharmacologyChemical-induced nephrotoxicity mediated by glutathione S-conjugate formation
2001, Toxicology Letters
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Present address: Istituto di Anatomia e Istologia Patologica, Università, Torino, Italy.