Using microfluidics to understand the effect of spatial distribution of tissue factor on blood coagulation
References (16)
- et al.
Tissue factor in thrombosis and hemorrhage
Surgery
(2007) - et al.
Regulation of tissue factor initiated thrombin generation by the stoichiometric inhibitors tissue factor pathway inhibitor, antithrombin-III, and heparin cofactor-II
J Biol Chem
(1997) - et al.
Calcium threshold in human plasma clotting kinetics
Thromb Res
(1994) - et al.
The role of membrane patch size and flow in regulating a proteolytic feedback threshold on a membrane: possible application in blood coagulation
Math Biosci
(2001) - et al.
Characterization of the threshold response of initiation of blood clotting to stimulus patch size
Biophys J
(2007) Role of tissue factor in hemostasis, thrombosis, and vascular development
Arterioscler Thromb Vasc Biol
(2004)Tissue factor: A key molecule in hemostatic and nonhemostatic systems
Int J Hematol
(2004)- et al.
Circulating tissue factor and thrombosis
Curr Opin Hematol
(2000)
Cited by (16)
Microfluidic devices for studying coagulation biology
2021, Seminars in Cell and Developmental BiologyCitation Excerpt :This same technique can also be used to examine how characteristics of the injury surface affect coagulation and thrombosis, as well as to define the kinetics of platelet recruitment, adhesion, and clot contraction. By designing a microfluidic device that incorporated varied spatial distributions of tissue factor, studies were able to demonstrate that the initiation of coagulation requires a large patch of tissue factor or a close distribution of many small patches, since a spread out distribution of small patches with the same total surface area did not initiate coagulation [41]. Atherosclerotic geometries have also been incorporated into microfluidic devices to study how disease states affect thrombosis.
Advances in microfluidics in combating infectious diseases
2016, Biotechnology AdvancesCitation Excerpt :As sepsis can be associated with systemic intravascular activation of coagulation (Aird, 2005), it is useful to learn about the spatial distribution and location of tissue factor (TF) and the geometry of the vasculature that regulate coagulation. Shen et al. developed microfluidic systems with surfaces of phospholipid bilayers patterned with TF to demonstrate experimentally the threshold responses of initiation of coagulation to the size and shape of surfaces presenting TF (Shen et al., 2008). Thermal injury can trigger an inflammatory cascade that heralds shock, SIRS and even death (D'Avignon et al., 2010).
Hemostasis and thrombosis beyond biochemistry: Roles of geometry, flow and diffusion
2015, Thrombosis ResearchMicrofluidic technology as an emerging clinical tool to evaluate thrombosis and hemostasis
2015, Thrombosis ResearchCitation Excerpt :Perhaps such an evaluation could soon be possible with recent advances in microfluidic assays that have provided the ability to investigate pathological shear stresses in channels that mimic stenotic vessels [41] or those with resultant turbulent flow. Similarly, microfluidic assays have been used to evaluate the spatial distribution of tissue factor on coagulation, which may have bearing on treatment of sepsis-related disseminated intravascular coagulation or venous thromboembolism [42]. Another promising trend is the use of microfluidics to evaluate patient-specific thrombotic potential and response to specific pro-coagulant agents such as chemotherapy [43].
Spatial aspects of blood coagulation: Two decades of research on the self-sustained traveling wave of thrombin
2015, Thrombosis ResearchCitation Excerpt :The first one is the group of Prof. Ataullakhanov that after the initial publications [21,33–35] continued to explore the processes of clot growth in non-convective systems in vitro [46–51,56–64]. The second one is the group of Prof. Ismagilov that carried out a series of significant research works using the microfluidics technique [52–54,65–71]. The propagation of self-sustained traveling waves in various homogeneous active media progresses at a constant stationary speed that does not depend on the manner of the wave initiation [31].
Simulated surface-induced thrombin generation in a flow field
2011, Biophysical JournalCitation Excerpt :This assumption breaks down as the dimensions of the boundary volume increase, as would occur, for example, at low shear rates and for large reaction areas, due to the potential for substrate depletion and product accumulation at the surface or at upstream sites. In contrast, although models incorporating spatial effects have recently been reported (8–10), most describe only reaction and diffusion and do not include convective effects. Recently, Leiderman and Fogelson (11) reported a spatiotemporal model of coagulation and platelet deposition over a short segment of exposed subendothelium under flow.