Elsevier

The Lancet

Volume 358, Issue 9292, 3 November 2001, Pages 1515-1516
The Lancet

Research Letters
Urothelial malignant disease and Chinese herbal nephropathy

https://doi.org/10.1016/S0140-6736(01)06576-XGet rights and content

Summary

We have previously reported occurrence of a specific type of nephropathy due to ingestion of Chinese herbs (Chinese herbal nephropathy [CHN]) in two patients in the UK. These cases highlighted the role of aristolochic acid in causing this nephropathy, which was first described in a Belgian cohort. We now report development of invasive transitional cell carcinoma of the urinary tract associated with the presence of aristolochic acid-DNA adducts in one of these patients. This work clearly shows the carcinogenic potential of aristolochic acid in this new type of nephropathy.

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