Preliminary CommunicationsCHROMOSOME ABERRATIONS AND EXPOSURE TO AMBIENT BENZENE
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Cited by (69)
Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review
2016, Mutation Research - Reviews in Mutation ResearchCitation Excerpt :The carcinogenicity of benzene is contingent on metabolic activation, with benzoquinones in the bone marrow implicated in the ultimate toxicity. Benzene leads to genotoxic effects at the hematopoietic stem cell level; specifically, DNA double strand breaks and chromosomal aberrations that are known to be causative of hematopoietic cancers occur in benzene-exposed human patients [109–111]. Benzene induced global DNA hypomethylation in human lymphoblastoid TK6 cells at concentrations of 1, 10, and 100 μM [112].
Gap junction intercellular communication and benzene toxicity
2010, Chemico-Biological InteractionsCitation Excerpt :The underlying mechanisms are, however, poorly understood, although metabolism has been shown to be required for the induced toxicological effects. Chromosomal aberrations [21–24], sister chromatid exchange [25], micronuclei formation [26,27], chromosomal loss and DNA strand breaks [28,29] have been observed, but the role of direct DNA reactivity, DNA adducts and mutations in benzene toxicity is still questioned [30]. The ring-opened six-carbon benzene metabolite trans,trans-muconaldehyde (MUC) has been shown to cause bone marrow depression [31] and reduced erythropoiesis in mice [32], and is one of the most potent bone marrow depressive benzene metabolites.
The benzene metabolite trans,trans-muconaldehyde blocks gap junction intercellular communication by cross-linking connexin43
2008, Toxicology and Applied PharmacologyEvaluation of sister chromatid exchange and chromosomal aberration frequencies in peripheral blood lymphocytes of gasoline station attendants
2005, Ecotoxicology and Environmental SafetyGenotoxicity of benzene and its metabolites
2004, Mutation Research - Reviews in Mutation ResearchFactors that contribute to biomarker responses in humans including a study in individuals taking Vitamin C supplementation
2001, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis