4-Substituted proline derivatives that inhibit angiotensin converting enzyme and neutral endopeptidase 24.11.

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Abstract

Analogs of captopril and enalapril with a thiorphan-like substituent at the 4-position of the proline ring were synthesized and found to be dual inhibitors of angiotensin converting enzyme (ACE) and neutral endopeptidase 24.11 (NEP).

Analogs of captopril and enalapril with a thiorphan-like substituent at the 4-position of the proline ring were synthesized and found to be dual inhibitors of angiotensin converting enzyme (ACE) and neutral endopeptidase 24.11 (NEP).

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