Elsevier

Annals of Epidemiology

Volume 19, Issue 3, March 2009, Pages 161-171
Annals of Epidemiology

An International Case-Control Study of Adult Diet and Brain Tumor Risk: A Histology-Specific Analysis by Food Group

https://doi.org/10.1016/j.annepidem.2008.12.010Get rights and content
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Purpose

Existing studies of diet and adult brain tumors have been limited by small numbers in histology-specific subgroups. Dietary data from an international collaborative case–control study on adult brain tumors were used to evaluate associations between histology-specific risk and consumption of specific food groups.

Methods

The study included 1548 cases diagnosed between 1984 and 1991 and 2486 control subjects from 8 study centers in 6 countries. Of the 1548 cases, 1185 were gliomas, 332 were meningiomas, and 31 were other tumor types. Dietary consumption was measured as average grams per day.

Results

We found inverse associations between some vegetable groups and glioma risk, the strongest for yellow-orange vegetables (odds ratio [OR], 0.7, 95% confidence interval [CI], 0.5–0.9 for the 4th vs. 1st quartile of consumption, p for trend < 0.001), and the association was limited to specific glioma subtypes. There was no association with cured meat. Non-cured meat was associated with a modest increase in glioma risk (OR, 1.3; 95% CI, 1.0–1.7 for 4th quartile vs. 1st quartile, p for trend = 0.01). We also found positive associations between egg, grain, and citrus fruit consumption and glioma but not meningioma risk.

Conclusions

Our study suggests that selected dietary food groups may be associated with adult gliomas and its subtypes but not meningiomas.

Key words

Brain Tumors
Diet
Glioma
Meningioma
N-Nitroso Compounds
Vegetables

Selected Abbreviations and Acronyms

NOC
N-nitroso compounds
IARC
International Agency for Research on Cancer
OR
odds ratio
95% CI
95% confidence interval

Cited by (0)

Funding in part was made possible by the National Cancer Institute NCI K07CA90685.

Deceased.