Brief ReportAbnormal Corpus Callosum Integrity in Bipolar Disorder: A Diffusion Tensor Imaging Study
Section snippets
Participants
The Structured Clinical Interview for DSM-IV Axis I Disorders Version 2.0 (SCID) (6) confirmed the presence or absence of Axis I Disorders and mood state at scanning for the 33 BD and 40 healthy comparison (HC) participants studied. Symptoms were assessed with the Hamilton Depression Rating Scale (HAMD) (7) and Clinician-Administered Rating Scale for Mania (CARS-M) (8). No subject had a history of neurological illness, head trauma with loss of consciousness over 5 min, or major medical
Results
The BD and HC groups did not differ significantly in age, gender, or SES scores (p values > .1). Data adhered to a normal distribution.
Discussion
With complementary ROI- and voxel-based DTI methods, we found decreased FA values in the participants with BD compared with HC participants in anterior and middle CC subregions encompassing the genu, rostral body, and the anterior portion of the midbody. The interhemispheric white matter connections of the CC are critical to interhemispheric communication and to the integration of emotional, cognitive, motor, and sensory information. Abnormalities in interhemispheric functioning in BD have been
References (20)
- et al.
Cognitive impairment and cerebral structure by MRI in bipolar disorder
Biol Psychiatry
(1990) - et al.
The Clinician-Administered Rating Scale for Mania (CARS-M): Development, reliability, and validity
Biol Psychiatry
(1994) - et al.
Estimation of the effective self-diffusion tensor from the NMR spin echo
J Magn Reson B
(1994) - et al.
Voxel based versus region of interest analysis in diffusion tensor imaging of neurodevelopment
Neuroimage
(2007) - et al.
Development of the corpus callosum in childhood, adolescence and early adulthood
Life Sci
(2002) Organic Nervous Disease
(1903)- et al.
Corpus callosum areas in first-episode patients with bipolar disorder
Psychol Med
(2007) - et al.
White matter abnormalities observed in bipolar disorder: A diffusion tensor imaging study
Bipolar Disord
(2007) - et al.
Corpus callosum signal intensity in patients with bipolar and unipolar disorder
J Neurol Neurosurg Psychiatry
(2004) - et al.
Structured Clinical Interview for DSM-IV Axis I & II Disorders (Version 2.0)
(1995)
Cited by (117)
White matter modifications of corpus callosum in bipolar disorder: A DTI tractography review
2023, Journal of Affective DisordersAlterations in the fronto-limbic network and corpus callosum in borderline-personality disorder
2020, Brain and CognitionWhite matter – emotion processing activity relationships in youth offspring of bipolar parents
2019, Journal of Affective DisordersExploring mania-associated white matter injury by comparison with multiple sclerosis: a diffusion tensor imaging study
2018, Psychiatry Research - Neuroimaging