Cell
Volume 148, Issues 1–2, 20 January 2012, Pages 273-284
ArticleGene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube
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open access
Graphical Abstract
Highlights
► Shh morphogen produces a dynamic gradient of Gli activity in the neural tube ► The dynamics of Gli activity are interpreted by a downstream transcriptional network ► The regulatory logic of the network explains both spatial and temporal gene responses ► The network confers hysteresis and robustness to fluctuations in signaling
Cited by (0)
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These authors contributed equally to this work
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Present address: Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Copyright © 2012 Elsevier Inc.