Letter to the EditorA novel pattern (sW195a) in surface gene of HBV DNA due to YSDD (L180M plus M204S) mutation selected during lamivudine therapy and successful treatment with adefovir dipivoxil
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Lamivudine and adefovir resistance in children and young adults with chronic hepatitis B
2010, International Journal of Infectious DiseasesCitation Excerpt :In YMDD mutation, isoleucine or valine replaced methionine in the YMDD pattern of DNA polymerase dependent on RNA in the HBV-resistant strain. There are also other mutations in which methionine and serine are replaced in the YMDD pattern and leucine and methionine are replaced in the amino acid substitutions in codon 180 and codon 181.21,22 The mutation profile was heterogeneous in the patient group made up of 24 patients, all of whom were reported with genotype D. rt80 I/V, rt204 YMDD/YVDD/YIDD, rt180 M/ FLL+FLM, and rt173 L mutations were observed in various combinations.
Demonstration of mutations conferring resistance to lamivudine in liver tissue of chronic hepatitis B patients under lamivudine therapy
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2005, Turkish Journal of Medical Sciences
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