Original researchAlcohol consumption and the risk of mucinous and nonmucinous epithelial ovarian cancer☆
Section snippets
Materials and methods
This analysis is based on the Study of Health and Reproduction Project, a case–control study of contraceptive and reproductive risk factors for epithelial ovarian cancer. Details of this study have been described elsewhere.36, 37 Briefly, cases were women aged 20–69 years diagnosed with incident epithelial ovarian cancer within the 9 months before interview. Between May 1994 and July 1998, 873 eligible women were identified at 39 hospitals around the Delaware Valley. Fourteen physicians did not
Results
Among the 761 cases, 112 (14.7%) were classified as mucinous tumors and 649 (85.3%) were classified as nonmucinous tumors. This histologic distribution is consistent with other studies.22, 38, 39 Table 1 shows the demographic and risk factor data for controls, for all cases, and for cases according to mucinous or nonmucinous subtype. The two case groups were similar except for age and cigarette use. Consistent with other studies,19, 21, 22 women who developed mucinous tumors were younger and
Discussion
In this study, we investigated the association of alcohol consumption with mucinous and nonmucinous epithelial ovarian cancer. Our data suggest that heavy alcohol consumption is associated with mucinous ovarian tumors but not nonmucinous tumors. The association is stronger for current heavy drinkers and might vary according to type of alcohol consumed. In particular, heavy consumption of spirits was more strongly associated with the risk of mucinous tumors than was heavy consumption of beer or
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Cited by (42)
Adult lifetime alcohol consumption and invasive epithelial ovarian cancer risk in a population-based case-control study
2016, Gynecologic OncologyCitation Excerpt :Another strength is the re-review of pathology slides to determine contemporary histotypes [20]. However, even with our large sample size and standardized review we had limited ability to investigate rare histotypes, such as the mucinous histotype, and alcohol consumption has been associated with an increased risk for this histotype [17,29]. Our study has other limitations.
Alcohol drinking and epithelial ovarian cancer risk. A systematic review and meta-analysis
2012, Gynecologic OncologyCitation Excerpt :Further, we excluded four publications [16–19] whose information was included in a pooled analysis of original data [8], that was retained for meta-analysis. Thus, the present analyses are based on 27 studies, including 23 case–control [6,7,9,12,13,20–37], 3 cohort [10,11,14] studies and the aforementioned pooled analysis of prospective cohort studies [8]. Furthermore, two included publications [31,37] were from the same case–control study: the former [31] included borderline epithelial ovarian cancer cases, the latter [37] invasive cases.
Ovarian Cancer Hormonal and Environmental Risk Effect
2007, Obstetrics and Gynecology Clinics of North AmericaCitation Excerpt :The data on the influence of alcohol intake on the risk of ovarian cancer have been inconsistent, with several studies showing no association between risk of ovarian cancer and total alcohol intake [51,52]. One study demonstrated that current heavy consumption of alcohol (24 g or more per day) might be a risk factor for mucinous epithelial ovarian cancer [53]. Caffeine intake has been studied also, and its effects on the risk of ovarian cancer also are inconsistent.
Alcohol intake and the risk of epithelial ovarian cancer
2023, Cancer Causes and Control
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Supported in part by the National Cancer Institute grants R01CA61095, R25 CA57703-06A1, and K07-CA80668-01A1.