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The virulence of clinical and environmental isolates of Campylobacter jejuni

Published online by Cambridge University Press:  19 October 2009

D. G. Newell ,
H. McBride ,
F. Saunders ,
Y. Dehele  and
A. D. Pearson
D. G. Newell
Affiliation:
Public Health Service Laboratory, Southampton General Hospital, Southampton SO9 4XY, U.K.
H. McBride
Affiliation:
Public Health Service Laboratory, Southampton General Hospital, Southampton SO9 4XY, U.K.
F. Saunders
Affiliation:
Public Health Service Laboratory, Southampton General Hospital, Southampton SO9 4XY, U.K.
Y. Dehele
Affiliation:
Public Health Service Laboratory, Southampton General Hospital, Southampton SO9 4XY, U.K.
A. D. Pearson
Affiliation:
Public Health Service Laboratory, Southampton General Hospital, Southampton SO9 4XY, U.K.
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Summary

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The virulence of Campylobacter jejuni and C. coli isolated from various water sources was compared with that of clinical strains by in vitro assays of adhesion, invasion and cytotoxicity to HeLa cells. Variation in degree of attachment was observed, but this did not appear to be related to strain source, However, water strains were less invasive and less cytotoxic to HeLa cells than clinical strains as shown by immunofluorescence and electron microscopy.

These differences were particularly evident between clinical and water isolates of the same serotype and biotype implicated in an outbreak of campylobacter enteritis in a school. The enhanced virulence of the clinical isolates, possibly induced by passage, was confirmed by colonization tests on infant mice.

Type
Research Article
Information
Journal of Hygiene , Volume 94 , Issue 1 , February 1985 , pp. 45 - 54
Copyright
Copyright © Cambridge University Press 1985

References

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