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Voltage gating of ion channels

Published online by Cambridge University Press:  17 March 2009

F. J. Sigworth
F. J. Sigworth
Affiliation:
Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven CT 06510, USA
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Extract

Voltage-gated ion channels are membrane proteins that play a central role in the propagation and transduction of cellular signals (Hille, 1992). Calcium ions entering cells through voltage-gated calcium channels serve as the trigger for neurotransmitter release, muscle contraction, and the release of hormones. Voltage-gated sodium channels initiate the nerve action potential and provide for its rapid propagation because the ion fluxes through these channels regeneratively cause more channels to open.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 27 , Issue 1 , February 1994 , pp. 1 - 40
Copyright
Copyright © Cambridge University Press 1994

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