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Measuring Change in Quality of Life in Response to Helicobacter pylori Eradication in Peptic Ulcer Disease

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Abstract

This study was designed to determine if a new condition-specific quality of life measure, the Quality Of Life in Reflux And Dyspepsia (QOLRAD), was responsive to clinical change over a four-week period when evaluating peptic ulcer disease patients undergoing Helicobacter pylori (Hp) eradication. A secondary aim was to evaluate QOLRAD's psychometric performance. Hp-positive patients with peptic ulcer disease were recruited from primary care and gastroenterology clinics (N = 155). QOLRAD scores improved significantly (P < 0.0001) and mean total score increase was 1.07 points on a 7-point scale among 111 subjects who responded to Hp eradication. Effect sizes were moderate for responders (0.64) and low for nonresponders (0.36). Score changes below 0.60 were associated with the smallest improvement in patient and physician condition rating; scores above 1.2 were associated with the greatest improvement. The QOLRAD demonstrates reliability and validity. Changes in QOLRAD score can be meaningfully related to clinical changes, aiding evaluation of health-related quality of life in peptic ulcer disease.

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REFRENCES

  1. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease: Helicobacter pylori in peptic ulcer disease. JAMA 272:65–69, 1994

    Google Scholar 

  2. Sonnenberg A, Everhart JE: Health impact of peptic ulcer in the United States. Am J Gastroenterol 92:614–620, 1997

    Google Scholar 

  3. Marshall BJ, Warren JR: Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1(8336):1273–1275, 1984

    Google Scholar 

  4. Soll AH: Consensus conference. Medical treatment of peptic ulcer disease. Practice guidelines. Practice Parameters Committee of the American College of Gastroenterology. JAMA 275:622–629, 1996

    Google Scholar 

  5. Levenstein S, Ackerman S, Kiecolt-Glaser JK, Dubois A: Stress and peptic ulcer disease. JAMA 281:10–11, 1999

    Google Scholar 

  6. Blum AL, Talley NJ, O'Morain C, van Zanten SV, Labenz J, Stolte M, Louw JA, Stubberod A, Theodors A, Sundin M, Bolling-Sternevald E, Junghard O: Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med 339:1875–1881, 1998

    Google Scholar 

  7. Lazzaroni M, Bargiggia S, Sangaletti O, Maconi G, Boldorini M, Bianchi Porro G: Eradication of Helicobacter pylori and long-term outcome of functional dyspepsia. A clinical endoscopic study. Dig Dis Sci 41:1589–1594, 1996

    Google Scholar 

  8. Holtmann G, Goebell H, Holtmann M, Talley NJ: Dyspepsia in healthy blood donors. Pattern of symptoms and association with Helicobacter pylori. Dig Dis Sci 39:1090–1098, 1994

    Google Scholar 

  9. Martin C, Marquis P, Bonfils S: A 'quality of life questionnaire' adapted to duodenal ulcer therapeutic trials. Scand J Gastroenterol 29(suppl 206):40–43, 1994

    Google Scholar 

  10. Shaw M, Talley NJ, Adlis S, Beebe T, Tomshine P, Healey M: Development of a digestive health status instrument: Tests of scaling assumptions, structure and reliability in a primary care population. Aliment Pharmacol Ther 12:1067–1078, 1998

    Google Scholar 

  11. Cutts TF, Abell TL, Karas JG, Kuns J: Symptom improvement from prokinetic therapy corresponds to improved quality of life in patients with severe dyspepsia. Dig Dis Sci 41:1369–1378, 1996

    Google Scholar 

  12. Moyer CA, Fendrick AM: Measuring health-related quality of life in patients with upper gastrointestinal disease. Dig Dis 16:315–324, 1998

    Google Scholar 

  13. Wiklund IK, Junghard O, Grace E, Talley NJ, Kamm M, Veldhuyzen van Zanten S, Pare P, Chiba N, Leddin DS, Bigard M-A, Colin R, Schoenfeld P: Quality of life in reflux and dyspepsia patients. Psychometric documentation of a new disease-specific questionnaire (QOLRAD). Eur J Surg Suppl 583:41–49, 1998

    Google Scholar 

  14. Svedlund J, Sjodin I, Dotevall G: GSRS-a clinical rating scale for gastrointestinal symptoms in patients with IBS and peptic ulcer disease. Dig Dis Sci 33:129–134, 1988

    Google Scholar 

  15. Dimenäs E, Glise H, Hallerbäck B, Hernqvist H, Svedlund J, Wiklund I: Well-being and gastrointestinal symptoms among patients referred to endoscopy owing to suspected duodenal ulcer. Scand J Gastroenterol 30:1046–1052, 1995

    Google Scholar 

  16. Dimenäs E, Glise H, Hallerbäck B, Hernqvist H, Svedlund J, Wiklund I: Quality of life in patients with upper gastrointestinal symptoms. An improved evaluation of treatment regimens? Scand J Gastroenterol 28:681–687, 1993

    Google Scholar 

  17. Revicki DA, Wood M, Wiklund I, Crawley J: Reliability and validity of the gastrointestinal symptom rating scale in patients with gastroesophageal reflux disease. Qual Life Res 7:75–83, 1998

    Google Scholar 

  18. Guyatt GH, Deyo RA, Charlson M, Levine MN, Mitchell A: Responsiveness and validity in health status measurement: A clarification. J Clin Epidemiol 42:403–408, 1989

    Google Scholar 

  19. Lydick EG, Epstein RS: Clinical significance of quality of life data. In Quality of Life and Pharmacoeconomics in Clinical Trials. B Spilker (ed). Philadelphia, Lippincott-Raven Publishers, 1996, pp 461–466

    Google Scholar 

  20. Kazis LE, Anderson JJ, Meenan RF: Effect sizes for interpreting changes in health status. Med Care 27(suppl 3):S178–S189, 1989

    Google Scholar 

  21. Katz JN, Gelberman RH, Wright EA, Lew RA, Liang MH: Responsiveness of self-reported and objective measures of disease severity in carpal tunnel syndrome. Med Care 32:1127–1133, 1994

    Google Scholar 

  22. Cohen J: Statistical Power Analyses for the Behavioral Sciences, 2nd ed. Hillsdale, New Jersey, Erlbaum, 1988

    Google Scholar 

  23. Jachuck SJ, Brierley H, Jachuck S, Wilcox PM: The effect of hypotensive drugs on the quality of life. J R Coll Gen Pract 32(235):103–105, 1982

    Google Scholar 

  24. Mant JWF, Jenkinson C, Murphy MFG, Clipsham K, Marshall PO, Vessey MP: Use of the Short Form-36 to detect the influence of upper gastrointestinal disease on self-reported health status. Qual Life Res 7:221–226, 1998

    Google Scholar 

  25. Dimenäs E: Methodological aspects of evaluation of quality of life in upper gastrointestinal diseases. Scand J Gastroenterol 23(suppl 199):18–21, 1993

    Google Scholar 

  26. Wiklund I, Butler-Wheelhouse P: Psychosocial factors and their role in symptomatic gastroesophageal reflux disease and functional dyspepsia. Scand J Gastroenterol 31(suppl 220): 94–100, 1996

    Google Scholar 

  27. Dimenäs E, Carlsson G, Glise H, Israelsson B, Wiklund I: Relevance of norm values as part of the documentation of quality of life instruments for use in upper gastrointestinal disease. Scand J Gastroenterol 31(suppl 221):8–13, 1996

    Google Scholar 

  28. Wilhelmsen I: Quality of life and Helicobacter pylori eradication. Scand J Gastroenterol 31(suppl 221):18–20, 1996

    Google Scholar 

  29. Shaw MJ, Adlis SA, Beebe TJ, Talley NJ, Kane RL: When does simple heartburn become a disease? Digestive Disease Week, May 1999; Orlando, Florida. Gastroenterology 116(4):A-956, 1999 (abstract)

    Google Scholar 

  30. Garrat AM, Ruta DA, Russell I, Macleod K, Brunt P, McKinlay A, Mowat A, Sinclair T: Developing a conditionspecific measure of health for patients with dyspepsia and ulcer-related symptoms. J Clin Epidemiol 49:565–571, 1996

    Google Scholar 

  31. Drossman DA, Funch-Jensen P, Janssens J, Talley NJ, Thompson WG, Whitehead WE: Identification of subgroups of functional gastrointestinal disorders. Gastroenterol Int 3:159–172, 1990

    Google Scholar 

  32. Fendrick AM, Chernew ME, Hirth RA, Bloom BS: Alternative management strategies for patients with suspected peptic ulcer disease. Ann Intern Med 123:260–268, 1995

    Google Scholar 

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Crawley, J., Frank, L., Joshua-Gotlib, S. et al. Measuring Change in Quality of Life in Response to Helicobacter pylori Eradication in Peptic Ulcer Disease. Dig Dis Sci 46, 571–580 (2001). https://doi.org/10.1023/A:1005655317121

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  • DOI: https://doi.org/10.1023/A:1005655317121

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