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Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling

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Abstract

Long chain acylCoA esters (LCAs) act both as substrates and intermediates in intermediary metabolism and as regulators in various intracellular functions. AcylCoA binding protein (ACBP) binds LCAs with high affinity and is believed to play an important role in intracellular acylCoA transport and pool formation and therefore also for the function of LCAs as metabolites and regulators of cellular functions [1]. The major factors controlling the free concentration of cytosol long chain acylCoA ester (LCA) include ACBP [2], sterol carrier protein 2 (SCP2) [3] and fatty acid binding protein (FABP) [4]. Additional factors affecting the concentration of free LCA include feed back inhibition of the acylCoA synthetase [5], binding to acylCoA receptors (LCA-regulated molecules and enzymes), binding to membranes and the activity of acylCoA hydrolases [6].

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References

  1. Færgemann NJ, Knudsen J: The role of long-chain fatty acids in regulation of metabolism and in cell signalling. Biochem J 323: 1–12, 1997

    Google Scholar 

  2. Knudsen J, Mandrup S, Rasmussen JT, Andreasen PH, Poulsen, F, Kristiansen K: The function of acyl-CoA-binding protein (ACBP/diazepam binding inhibitor (DBI). Mol Cell Biochem 123: 129–138, 1993

    Google Scholar 

  3. Frolow A, Cho T, Billheimer JT, Schroeder F: Sterol carrier protein-2 a new fatty acid coenzyme A-binding protein. J Biol Chem 271: 31878–31884, 1996

    Google Scholar 

  4. Glatz JFC, van der Vusse GJ: Cellular fatty acid-binding proteins: Their function and physiological significance. Prog Lipid Res 35: 243–282, 1996

    Google Scholar 

  5. Pande SV: Reversal by CoA of palmityl-CoA inhibition of long chain acyl-CoA synthetase activity. Biochim Biophys Acta 306: 15–20, 1973

    Google Scholar 

  6. Berge RK, Slinde E, Farstad M: Intracellular localization of long-chain acyl-coenzyme A hydrolase and acyl-L-carnitine hydrolase in brown adipose tissue from guinea pigs. Biochem J 182: 347–351, 1979

    Google Scholar 

  7. Mogensen IB, Schulenberg H, Hansen HO, Spener F, Knudsen J: A novel acyl-CoA-binding protein from bovine liver. Effect on fatty acid synthesis. Biochem J 214: 189–192, 1987

    Google Scholar 

  8. Kragelund BB, Hojrup P, Jensen MS, Chjerling CK, Juul E, Knudsen J, Poulsen FM: Fast and one-step folding of closely and distantly related homologous proteins of four-helix bundle family. J Mol Biol 256: 187–200, 1996

    Google Scholar 

  9. Mikkelsen J, Knudsen J: Acyl-CoA-binding protein from cow. Binding characteristics and cellular and tissue distribution. Biochem J 248: 709–714, 1987

    Google Scholar 

  10. Fyrst H, Knudsen J, Schott MA, Lubin BH, Kuypers FA: Detection of acyl-CoA-binding protein in human red blood cells and investigation of its role in membrane phospholipid renewal. Biochem J 306: 793–799, 1995

    Google Scholar 

  11. Alho HE, Costa P, Ferrero M, Fujimoto D, Cosenza Murphy, Guidotti A: Diazepam-binding inhibitor: A neuropeptide located in selected neuronal populations of rat brain. Science 229: 179–182, 1985

    Google Scholar 

  12. Bovolin P, Schlichting J, Miyata M, Ferrarese C, Guidotti A, Alho H: Distribution and characterization of diazepam binding inhibitor (DBI) in peripheral tissues of rat. Regul Pept 29: 267–281, 1990

    Google Scholar 

  13. Pusch W, Balvers M, Hunt N, Ivell R: A novel endozepine-like peptide (ELP) is exclusively expressed in male germ cells. Mol Cell Endocrinol 122: 69–80, 1996

    Google Scholar 

  14. Kolmer M, Roos C, Tirronen M, Myohanen S, Alho H: Tissue-specific expression of diazepam-binding inhibitor in Drosophila melanogaster: Cloning, structure, and localization of the gene. Mol Cell Biol 14: 6983–6995, 1994

    Google Scholar 

  15. Mandrup S, Hummel R, Ravn S, Jensen G, Andreasen PH, Gregersen N, Knudsen J, Kristiansen K: Acyl-CoA-binding protein/diazepam-binding inhibitor gene and pseudogenes. A typical housekeeping gene gamily. J Mol Biol 228: 1011–1022, 1992

    Google Scholar 

  16. Robinson CV, Chung EW, Kragelund BB, Knudsen J, Aplin RT, Poulsen FM, Dobson CM: Probing the nature of noncovalent interations by mass spectrometry. A study of protein-CoA ligand binding and assembly. J Am Chem Soc 118: 8646–8653, 1996

    Google Scholar 

  17. Kragelund BB, Andersen KV, Madsen JC, Knudsen J, Poulsen FM: Three-dimensional structure of the complex between acyl-coenzyme A binding protein and palmitoyl-coenzyme A. J Mol Biol 230: 1260–1277, 1993

    Google Scholar 

  18. Færgeman NJ, Sigurskjold BW, Kragelund BB, Andersen KV, Knudsen J: Thermodynamics of ligand binding to acyl-coenzyme A binding protein studied by titration calorimetry. Biochemistry 35: 14118–14126, 1996

    Google Scholar 

  19. Rasmussen JT, Borchers T, Knudsen J: Comparison of the binding affinities of acyl-CoA-binding protein and fatty-acid-binding protein for long-chain acyl-CoA esters. Biochem J 265: 849–855, 1990

    Google Scholar 

  20. Rosendal J, Ertbjerg P, Knudsen J: Characterization of ligand binding to acyl-CoA-binding protein. Biochem J 290: 321–326, 1993

    Google Scholar 

  21. Rasmussen JT, Rosendal J, Knudsen J: Interation of acyl-CoA binding protein (ACBP) on processes for which acyl-CoA is a substrate, product or inhibitor. Biochem J 292: 907–913, 1993

    Google Scholar 

  22. Knudsen J, Færgemann NJ, Skott H, Hummel R, Borsting C, Rose TM, Andersen JS, Hojrup P, Roepstorff P, Kristiansen K: Yeast acyl-CoA-binding protein: Acyl-CoA-binding affinity and effect on intracellular acylo-CoA pool size. Biochem J 302: 479–485, 1994

    Google Scholar 

  23. Mandrup S, Jepsen R, Skott H, Rosendal J, Hojrup P, Kristiansen K, Knudsen J: Effect of heterologous expression of acyl-CoA-binding protein on acyl-CoA level and composition in yeast. Biochem J 290: 369–374, 1993

    Google Scholar 

  24. Schjerling CK, Hummel R, Hansen JK, Borsting C, Mikkelsen JM, Kristiansen K, Knudsen J: Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae. J Biol Chem 271: 22514–22521, 1996

    Google Scholar 

  25. Bortz WM, Lynen F: The inhibition of acetyl CoA carboxylase by long chaing acylCoA derivatives. Biochemische Zeitschrift 337: 505–509, 1963

    Google Scholar 

  26. Tardi PG, Man RY, Choy PC: The effect of methyl-lidocain on the biosynthesis of phospholipds de novo in the isolated hamster heart. Biochem J 285: 161–166, 1992

    Google Scholar 

  27. Rosendal J, Knudsen J: A fast and versatile method for extraction and quantitation of long-chain acyl-CoA esters from tissue: Content of individual long-chain acyl-CoA esters in various tissues from fed rat. Anal Biochem 207: 63–67, 1992

    Google Scholar 

  28. Corkey BE, Deeney JT: Acyl CoA regulation of metabolism and signal transduction. Prog Clin Biol Res 321: 217–232, 1990

    Google Scholar 

  29. Sterchele PF, van den Heuvel JP, Davis W, Shrago E, Knudsen J, Peterson RE: Induction of hepatic acyl-CoA-binding protein and liver fatty acid-binding protein by perfluorodecanoic acid in rats. Lack of correlation with hepatic long-chain acyl-CoA levels. Biochem Pharmacol 48: 955–966, 1994

    Google Scholar 

  30. Majumdar S, Rossi MW, Fujiki T, Phillips WA, Disa S, Queen CF, Johnston RB Jr, Rosen OM, Corkey BE, Korchak HM: Protein kinase C isotypes and signaling in neutrophils. Differential substrate specificities of a translocatable calcium-and phospholipid-dependent beta-protein kinase C and a phospholipid-dependent protein kinase which is inhibited by long chain fatty acyl coenzyme A. J. Biol Chem 266: 9285–9294, 1991

    Google Scholar 

  31. Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT, Corkey BE: Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. J Biol Chem 267: 5802–5810, 1992

    Google Scholar 

  32. Deeney JT, Tornheim K, Korchak HM, Prentki M, Corkey BE: Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells. J Biol Chem 267: 19840–19845, 1992

    Google Scholar 

  33. Tubbs PK, Garland PB: Variations in tissue contents of coenzyme A thio esters and possible metabolic implications. Biochem J 93: 550–557, 1964

    Google Scholar 

  34. Berge RK, Aarsland A, Bakke OM, Farstad M: hepatic enzymes, CoASH and long-chain acyl-CoA in subcellular fractions as affected by drugs inducing peroxisomes and smooth endoplasmic reticulum. Int J Biochem 15: 191–204

  35. Constantinides PP, Steim JM: Micellization of fatty acid acyl-CoA mixtures and its relevance to the fatty acyl selectivity of acyltransferases. Arch Biochem Biophys 261: 430–436, 1988

    Google Scholar 

  36. Tippet PS, Neet KE: Specific inhibition of glucokinase by long chain acyl coenzymes A below the critical micelle concentration. J Biol Chem 257: 12839–12845, 1982

    Google Scholar 

  37. Idell Wenger JA, Grotohann LW, Neely JR: Coenzyme A and carnitine distribution in normal and ischemic hearts. J Biol Chem 253: 4310–4318, 1978

    Google Scholar 

  38. Moore KH, Dandurand DM, Kiechle FL: Fasting induced alterations in mitochondrial palmitoyl-CoA metabolism may inhibit adipocyte pyruvate dehydrogenase activity. Int J Biochem 24: 809–814, 1992

    Google Scholar 

  39. Oram JF, Wenger JI, Neely JR: Regulation of long chain fatty acid activation in heart muscle. J Biol Chem 250: 73–78, 1975

    Google Scholar 

  40. Gossett RE, Frolov AA, Roths JB, Behnke WD, Kier AB, Schroeder F: Acyl-CoA binding proteins: Multiplicity and function. Lipids 31: 895–918, 1996

    Google Scholar 

  41. Rolf B, Oudenampsen Kruger E, Borchers T, Færgemann NJ, Knudsen J, Lezius A, Spener F: Analysis of the ligand binding properties of recombinant bovine liver-type fatty acid binding protein. Biochim Biophys Acta 1259: 245–253, 1995

    Google Scholar 

  42. Glatz JFC, van der Vusse GJ, Veerkamp JH: Fatty acid-binding proteins and their physiological significance. News Physiol Sci 35: 41–43, 1988

    Google Scholar 

  43. Webb NR, Rose TM, Malik N, Marquardt H, Shoyab M, Todaro GJ, Lee DC: Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand. DNA 6: 71–79, 1987

    Google Scholar 

  44. Todaro GJ, Rose TM, Shoyab M: Human DBI (endozepine): Relationship to a homologous membrane associated protein (MA-DBI). Neuropharmacology 30: 1373–1380, 1991

    Google Scholar 

  45. Peitzsch RM, McLaughlin S: Binding of acylated peptides and fatty acids to phospholipid vesicles: Pertinence to myristoylated proteins. Biochemistry 32: 10436–10443, 1993

    Google Scholar 

  46. Requero MA, Gonzalez M, Goni FM, Alonso A, Fidelio G: Differential penetration of fatty acyl-coenzyme A and fatty acylcarnitines into phospholipid monolayers. FEBS Lett 357: 75–78, 1995

    Google Scholar 

  47. Berge RK, Farstad M: Purification and characterization of long-chain acyl-CoA hydrolase from rat liver mitochondria. Eur J Biochim 96: 393–401, 1979

    Google Scholar 

  48. Berge RK, Hosoy LH, Aarsland A, Bakke OM, Farstad M: Enzymatic changes in rat liver associated with low and high doses of a peroxisome proliferator. Toxicol Appl Pharmacol 73: 35–41, 1984

    Google Scholar 

  49. Waku K: Origins and fates of fatty acyl-CoA esters. Biochim Biophys Acta 1124: 101–111, 1992

    Google Scholar 

  50. Knudsen J, Clark S, Dils R: Acyl-CoA hydrolase(s) in rabbit mammary gland which control the chain length of fatty acids synthesised. Biochem Biophys Res Commun 65: 921–926, 1975

    Google Scholar 

  51. Knudsen J, Clark S, Dils R: Purficiation and some properties of a medium-chain acyl-thioester hydrolase from lactating-rabbit mammary gland which terminates chain elongation in fatty acid synthesis. Biochem J 160: 683–691, 1976

    Google Scholar 

  52. Broustas CG, Hajra AK: Purification, properties and specificity of rat brain cytosolic fatty acyl coenzyme A hydrolase. J Neurochem 64: 2345–2353, 1995

    Google Scholar 

  53. Yamada J, Furihata T, Tamura H, Watanabe T, Suga T: Long-chain acyl-CoA hydrolase from rat brain cytosol: Purification, characterization and immunohistochemical localization. Arch Biochem Biophys 326: 106–114, 1996

    Google Scholar 

  54. Ogiwara H, Tanabe T, Nikawa J, Numa S: Inhibition of rat-liver acetyl-coenzyme-A caboxylase by palmitoyl-coenzyme A. Formation of equimola enzyme-inhibitor complex. Eur J biochem 89: 33–41, 1978

    Google Scholar 

  55. Rasmussen JT, Færgemann NJ, Kristiansen K, Knudsen J: Acyl-CoAbinding protein (ACBP) can mediate intermembrane acyl-CoA transport and donate acyl-CoA for beta-oxidation and glycerolipid synthesis. Biochem J 299: 165–170, 1994

    Google Scholar 

  56. Carling D, Zammit VA, Hardie DG: A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett 223: 217–222, 1987

    Google Scholar 

  57. Halperin ML, Pande SV: Fatty acyl group transport into mitochondria: Carnatine palmitoyl transferase EC 2.3.1.23 and the carnitine-acylcarnatine translocase. Methods Enzymol 56: 368–378, 1979

    Google Scholar 

  58. Lehrer G, Panini SR, Rogers DH, Rudney H: Modulation of rat liver 3–hydroxy-3–methylglutaryl coenzyme A reductase by lipid inhibitors, substrates and cytosolic factors. J Biol Chem 256: 5612–5619, 1981

    Google Scholar 

  59. Murthy MS, Pande SV: Some differences in the properties of carnitine palmitoyltransferase activities of the mitochondrial outer and inner membranes. Biochem J 248: 727–733, 1987

    Google Scholar 

  60. Powell PJ, Lau SM, Killian D, Thorpe C: Interaction of acyl coenzyme A substrates and analgues with pig kidney medium-chain acyl-CoA dehydrogenase. Biochemistry 26: 3704–3710, 1987

    Google Scholar 

  61. Jepson VA, Yeaman SJ: Inhibition of hormone-sensitive lipase by intermediary lipid metabolites. FEBS Lett 310: 197–200, 1992

    Google Scholar 

  62. Woldegoirgis G, Yousufzai SY, Shrago E: Studies on the interaction of palmutoyl coenzyme A with the adenine nucleotide translocase. J Biol Chem 257: 14783–14787, 1982

    Google Scholar 

  63. Tippett PS, Neet KE: An allosteric model for the inhibition of glucokinase by long chain acyl coenzyme A. J Biol Chem 257: 12846–12852, 1982

    Google Scholar 

  64. Fulceri R, Gamberucci A, Scott HM, Giunti R, Burchell A, Benedetti A: Fatty acyl-CoA esters inhibit glucose-6–phosphatase in rat liver microsomes. Biochem J 307: 391–397, 1995

    Google Scholar 

  65. Moore KH, Tsatso P, Staudacher DM, Kiechle FL: Counter modulation of adipocyte motochondrial processes by insulun and S-oxalylglutathione. Int J Biochem Cell Biol 28: 183–191, 1996

    Google Scholar 

  66. Fulceri R, Nori A, Gamberucci A, Volpe P, Giunti R, Benedetti A: Fatty acyl-CoA esters induce calcium release from terminal cisternae of skeletal muscle. Cell Calcium 15: 109–116, 1994

    Google Scholar 

  67. Chini EN, Dousa TP: Palmitoyl-CoA potentiates the Ca2+ release elicited by cyclic ADP-ribose. Am J Physiol 270: C530–C537, 1996

    Google Scholar 

  68. Rys Sikora Kem Ghosh TK, Gill DL: Modification of GTP-activated calcium translocation by fatty acyl-CoA esters. Evidence for a GTPinduced prefusion event. J Biol Chem 269: 31607–31613, 1994

    Google Scholar 

  69. Fulceri R, Gamberucci A, Bellomo G, Giunti R, Benedetti A: CoA and fatty acid acyl-CoA derivatives mobilize calcium from a liver reticular pool. Biochem J 295: 663–669, 1993

    Google Scholar 

  70. Siliprandi D, Biban C, Testa S, Toninello A, Siliprandi N: Effects of palitoyl CoA and palmitoyl carnitine on the mebrane potential and Mg2+ content of rat heart mitochondrial. Mol Cell Biochem 116: 117–123, 1992

    Google Scholar 

  71. Kaker SS, Huang WH, Askari A: Contro of cardiac sodium pump by long-chain acyl coenzymes A. J Biol Chem 262: 42–45, 1987

    Google Scholar 

  72. Hall Smith SC, Murray AG, Selwyn MJ: Palmyitoyl-CoA inhibits the mitochondrial inner membrane anion-conducting chanel. FEBD Lett 236: 155–158, 1988

    Google Scholar 

  73. Larsson O, Deeney JT, Branstrom R, Berggren PO, Corkey BE: Activation of ATP-sensitive K+ channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity. J Biol Chem 271: 10623–10626, 1996

    Google Scholar 

  74. Bronfman M, Morales MN, Orellana A: Diacylglycerol activation of protein kinase C is modulated by long-chain acyl-CoA. Biochem Biophys Res Commun 152: 987–992, 1988

    Google Scholar 

  75. Li Q, Yamamoto N, Morisawa S, Inoue A: Fatty acyl-CoA binding activity of the nuclear thyroid hormone receptor. J Cell Biochem 51: 458–464, 1993

    Google Scholar 

  76. DiRusso CC, Heimert TL, Metzger AK: Characterization of FadR, a global transciptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the FadB promoter is prevented by long chain fatty acy coenzyme A [published erratum appears in J Biol Chem 1992 Nov 5; 267(31): 22693] J Biol Chem 267: 8685–8691, 1992

    Google Scholar 

  77. Pfanner N, Glick BS, Arden SR, Rothman JE: Fatty acylation promotes fusion of transport vesicles with Golgi cisternae. J Cell Biol 110: 995–961, 1990

    Google Scholar 

  78. Pfanner N, Orci L, Glick BS, Amherdt M, Arden SR, Malhotra V, Rothman JE: Fatty acyl-coenzyme A is required for budding of transport vesicles from Golgi cisternae. Cell 59: 95–102, 1989

    Google Scholar 

  79. Comerford JG, Dawson AP: Effects of CoA and acyl-CoAs on GTPdependent Ca2+ release and vesicle fusion in rat liver microsomal vesicles. Biochem J 289: 561–567, 1993

    Google Scholar 

  80. Yamakawa N, Shimeno H, Soeda S, Nagamutsu A: Inhibition of proline endopeptidase activity by acyl-coenzyme A esters. Biochim Biophys Acta 1037: 302–306, 1990

    Google Scholar 

  81. Svensson LT, Kilpelainen SH, Hiltunen JK, Alexson SE: Characterization and isolation of enzymes that hydrolyze short-chain acyl-CoA in rat-liver mitochondria. Eur J Biochem 239: 526–531, 1996

    Google Scholar 

  82. Ong DE: Cellular transport and metabolism of vitamin A: Roles of the cellular retinoid-binding proteins. Nutr Rev 52: S24–S31, 1994

    Google Scholar 

  83. Boerman MH, Napoli JL: Cellular retinol-binding protein-supported retinoic acid synthesis. Relative rolse of microsomes and cytosol. J Biol Chem 271: 5610–5616, 1996

    Google Scholar 

  84. Numa S, Yamashita S: Regulation of lipogenosis in animal tissues. Curr Top Cell Regul 8: 197–246, 1974

    Google Scholar 

  85. Kamiryo T, Parthasarathy S, Numa S: Evidence that acyl coenzyme A synthetase activity is required for repression of yeast acetyl coenzyme A carboxylase by exogenous fatty acids. Proc Natl Acad Sci USA 73: 386–390, 1976

    Google Scholar 

  86. Choi JY, Stukey J, Hwang, SY, Martin CE: Regulatory elements that control transcription activation and unsaturated fatty acid-mediated repression of the Saccharomyces cerevisia OLE1 gene. J Biol Chem 271: 3581–3589, 1996

    Google Scholar 

  87. Raman N, DiRusso CC: Analysis of acyl coenzyme A binding to the transcription factor FadR and identification of amino acid residues in the carboxyl terminus required for ligand binding. J Biol Chem 270: 1092–1097, 1995

    Google Scholar 

  88. Baldursson T, Gram C, Knudsen J, Krisiansen K, Mandrup S: Adipocyte differentiation is dependent onthe induction of the acyl-CoA binding protein. NATO ASI Series, Vol H92: 365374, 1995

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  1. Biokemisk Institut, Odense Universitet, Odense M, Denmark

    Jens Knudsen, Mette Valentin Jensen, Nils J. F\sgmaelig;rgeman, Thomas B.F. Neergaard & Barbara Gaigg

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Knudsen, J., Jensen, M.V., F\sgmaelig;rgeman, N.J. et al. Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling. Mol Cell Biochem 192, 95–103 (1999). https://doi.org/10.1023/A:1006830606060

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