Abstract
The present study was conducted to test the hypothesis that exposure to influenza in pregnancy increases the risk of tumour of certain type in childhood. Children ages 17 years or less diagnosed in Greece with brain tumours or neuroblastomas from 1982 to 1993 (n=94) were contrasted to 210 controls selected from the same hospitals. Mothers of these children were interviewed about a variety of possible etiologic factors. The prevalence of influenza in Greece for each year during the period 1984–1992 was also compared with the number of children born during the same year who subsequently developed brain tumour or neuroblastoma. The results indicate a significant association between influenza in pregnant women and occurrence of tumour in index child (OR: 3.15, 95% CI: 1.13–8.77). These results persisted when adjustment for potential confounding factors was made. The findings should be interpreted cautiously because of lack of serologic documentation of information about infection obtained in interviews. A positive correlation (r = 0.74) of the number of tumour births by year of birth with the prevalence of influenza during the same year was also noted. This exploratory study is one of the few case-control studies of the epidemiology of childhood tumours in children, and the results suggest directions for future epidemiologic studies in this relatively uncharted field.
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References
Dworkin PH. The national medical series for independent study: Pediatrics. New York: John Wiley & Sons, 1987.
Gold EB, Gordis L, Tonascia J, Szklo M. Risk factors for brain tumours in children. Am J Epidemiol 1979; 109: 309–319.
Gold EB, Diener MD, Szklo M. Parental occupations and cancer in children: A case-control study and review of methodologic issues. J Occup Med 1982; 24: 578–584.
Wertheimer N, Leeper E. Electrical wiring configurations and childhood cancer. Am J Epidemiol 1979; 109: 273–284.
Preston-martin S, Yu MC, Benton B, Henderson BE. N-nitroso compounds and childhood brain tumours: A case-control study. Cancer Res 1982; 42: 5240–5245.
Olshan AF, Breslow NE, Daling JR, Weiss NS, Leviton A. Childhood brain tumours and parental occupation in the aerospace industry. J Natl Cancer Inst 1986; 77: 17–19.
Savitz DA, John EM, Kleckner RC. Magnetic field exposure from electric appliances and childhood cancer. Am J Epidemiol 1990; 1131: 763–773.
Wilkins JR III, Hundley VD. Paternal occupational exposure to electromagnetic fields and neuroblastoma in offspring. Am J Epidemiol 1990; 131: 995–1008.
Wilkins JR III, Sinks T. Parental occupation and intracranial neoplasms of childhood: Results of a case-control interview study. Am J Epidemiol 1990; 132: 275–292.
Savitz DA, Wachtel H, Barnes FA, John EM, Tvrdik JG. Case control study of childhood cancer and exposure to 60-Hz magnetic fields. Am J Epidemiol 1988; 128: 21–38.
Savitz DA, Feingold L. Association of childhood cancer with residential traffic density. Scand J Work Environ Health 1989; 15: 360–363.
Fedrick J, Alberman ED. Reported influenza in pregnancy and subsequent cancer in the child. Br Med J 1972; 2: 485–488.
Hakulinen T, Hovi L, Karkinen-Jaaskelainen M, Penttinen A, Saxen I. Associations between influenza during pregnancy and childhood leukaemia. Br Med J 1973; 4: 265–267.
Cloyd MW, Burger PC, Bigner DD. R-type virus-like particles in avian sarcoma virus-induced rat central nervous system tumours. J Natl Cancer Inst 1975; 54: 1479–1482.
Vick NA, Bigner DD. Gliomas induced by avian sarco mas virus (ASV): Early and sequential structural events of the neoplastic transformation in vivo. J Neuropathol Exp Neurol 1975; 34: 99–100.
Ida N, Ikawa Y, Ogawa K, et al. Cell culture from a rat brain tumour induced by intracerebral inoculation with marine sarcoma virus. J Natl Cancer Inst 1974; 53: 431–447.
Yohn DS. Oncogenic viruses: Expectation and applications in neuropathology. Prog Exp Tumor Res 1972; 17: 74–92.
Schuman LM, Choi NW, Gullen WH: Relationship of central nervous system neoplasms to toxoplasma gondii infection. Am J Public Health 1967; 57: 848–856.
Linet MS. The leukemias: Epidemiologic aspects. New York, Oxford: Oxford University Press, 1985.