Elsevier

Annals of Oncology

Volume 10, Issue 8, August 1999, Pages 961-964
Annals of Oncology

Original article
Hepatitis C infection and B-cell non-Hodgkin's lymphoma in British Columbia: A cross-sectional analysis

https://doi.org/10.1023/A:1008361311409Get rights and content
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Summary

Objectives

To determine the prevalence of hepatitis C virus (HCV) infection in patients with B-cell non-Hodgkin's lymphoma (NHL) in British Columbia.

Design

A cross-sectional analysis.

Setting

The British Columbia Cancer Agency (BCCA), a Canadian provincial tertiary oncology referral center.

Subjects

Consecutive patients with B-cell NHL registered onto the BCCA lymphoma database in 1996 and part of 1997 and a control group of patients with T-cell NHL registered on the database from 1995 through 1997. Patients with HIV infection were excluded from the analysis. A second control group (n = 1085) consisted of health-care workers tested for HCV infection following a needle-stick injury.

Interventions

Stored sera from patients with B-cell NHL (n = 88) and T-cell NHL (n = 37), identified from the database, were tested for the presence of HCV infection with commercially available serologic tests.

Main outcome measures

HCV seropositivity in the B-cell lymphoma group compared to the control groups (T-cell NHL and health-care workers).

Results

2.3% of the B-cell NHL group, none of the T-cell NHL group and 1% of the health-care worker control group were positive for HCV infection. These results were not statistically significantly different.

Conclusion

Patients in British Columbia with B-cell NHL do not have an increased prevalence of HCV infection. These data suggest that the lymphotrophism of HCV may differ by regional, racial and genotypic variations around the world.

Key words

Canada
hepatitic C
non-Hodgkin's lymphoma

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