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Genetically Engineered Mouse Models of Mammary Intraepithelial Neoplasia

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Abstract

Foci of atypical mammary epithelium have been associated with breast cancer in many species including mouse and man. The advent of targeted genomics has led to the creation of numerous genetically engineered mice (GEM)5 which display focal atypical lesions associated with mammary cancer. Some early lesions in GEM have a remarkable morphological similarity to pre-cancers in humans. While the malignant potential of atypical foci have been thoroughly documented in the non-GEM by tissue transplantation, a review of the literature reveals that precursor lesions in GEM remain incompletely described and only partially documented. Their validation as appropriate models of human breast preneoplasia awaits classical transplantation studies. Here, we review the literature characterizing early lesions of GEM models of mammary cancer, discuss the principles of the Focality, Atypia, and Association and present an introduction of mammary transplantation for model Validation.

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Authors and Affiliations

  1. Department of Pathology and Center for Comparative Medicine, University of California, One Shields Ave, Davis, California, 95616

    Robert D. Cardiff

  2. UCSD Cancer Center, School of Medicine, University of California, San Diego, 9500

    Drew Moghanaki

  3. Gilman Drive, La Jolla, California, 92093-0684

    Drew Moghanaki

  4. Department of Pathology, 4918 TVC, Vanderbilt University Medical Center, 22nd Avenue South and Pierce Avenue, Nashville, Tennessee, 37232-5310

    Roy A. Jensen

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Cardiff, R.D., Moghanaki, D. & Jensen, R.A. Genetically Engineered Mouse Models of Mammary Intraepithelial Neoplasia. J Mammary Gland Biol Neoplasia 5, 421–437 (2000). https://doi.org/10.1023/A:1009534129331

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