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Computing the Cox Model for Case Cohort Designs

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Abstract

Prentice (1986) proposed a case-cohort design as an efficient subsampling mechanism for survival studies. Several other authors have expanded on these ideas to create a family of related sampling plans, along with estimators for the covariate effects. We describe how to obtain the proposed parameter estimates and their variance estimates using standard software packages, with SAS and SPLUS as particular examples.

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Authors and Affiliations

  1. Section of Biostatisctics, Mayo Foundation, Rochester, MN, 55905

    Terry M. Therneau

  2. Rowe Program in Genetics, UC Davis School of Medicine, Davis, CA, 95616

    Hongzhe Li

Authors
  1. Terry M. Therneau
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  2. Hongzhe Li
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Therneau, T.M., Li, H. Computing the Cox Model for Case Cohort Designs. Lifetime Data Anal 5, 99–112 (1999). https://doi.org/10.1023/A:1009691327335

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