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Effects of Simvastatin on the Phospholipid Composition of High-Density Lipoproteins in Patients with Hypercholesterolemia

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Abstract

We studied the phospholipid composition of high-density lipoproteins in patients with hypercholesterolemia before and after treatment with simvastatin. Individual phospholipids were separated by thin-layer chromatography on glass plates coated with silica gel. It was found that apart from hypolipidemic effect, simvastatin changed the concentration and phospholipid composition of high-density lipoproteins, which improved their cholesterol-accepting and cholesterol-transporting properties.

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Authors and Affiliations

  1. Department of Metabolic Disorders, State Research Center of Preventive Medicine, Russian Ministry of Health, Moscow

    I. N. Ozerova, I. V. Paramonova, A. M. Olfer'ev, N. M. Akhmedzhanov, M. A. Aleksandrova & N. V. Perova

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  1. I. N. Ozerova
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  2. I. V. Paramonova
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  3. A. M. Olfer'ev
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  4. N. M. Akhmedzhanov
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  5. M. A. Aleksandrova
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  6. N. V. Perova
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Ozerova, I.N., Paramonova, I.V., Olfer'ev, A.M. et al. Effects of Simvastatin on the Phospholipid Composition of High-Density Lipoproteins in Patients with Hypercholesterolemia. Bulletin of Experimental Biology and Medicine 132, 763–765 (2001). https://doi.org/10.1023/A:1013034029290

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