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Quality of Life in Functional Dyspepsia

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Abstract

Our purpose was to assess the quality of life of functional dyspepsia patients using the SF-36 generic scale and the Gastrointestinal Symptoms Rating Scale (GSRS). In all, 328 dyspeptic patients were included in a multicenter, prospective, observational study. Both scales were filled out at baseline and one and three months after a prokinetic agent was given as a single-drug therapy. A total of 250 patients completed the study. An improvement in all SF-36 dimensions was observed, although the final scores were lower than the population reference values. Physical role (27% change), emotional role (20%), and physical pain (16%) dimensions showed the greater change. The GSRS total and domain scores also showed significant decreases. The best predictors of quality of life improvement were certain basal symptoms, drug compliance, and the absence of idiopathic dyspepsia. In conclusion, both the generic and the specific scales provide useful and sensitive measures of quality of life in functional dyspepsia patients on single-drug treatment.

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Authors and Affiliations

  1. Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Universidad Autónoma de Barcelona, Sant Antoni Ma Claret 167, 08026, Barcelona, Spain

    Joan Monés

  2. Department of Psychiatry and Clinical Psychobiology, Universidad Autónoma de Barcelona, Passeig Vall d'Hebrón 171, 08035, Barcelona, Spain

    Ana Adan

  3. Division of Pharma Consult Services, Pharma Research, S.A., Travessera de Gràcia 17-21, 08021, Barcelona, Spain

    José L. Segú, Juan S. López, Maite Artés & Tina Guerrero

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  1. Joan Monés
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  2. Ana Adan
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  3. José L. Segú
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  4. Juan S. López
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  5. Maite Artés
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  6. Tina Guerrero
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Monés, J., Adan, A., Segú, J.L. et al. Quality of Life in Functional Dyspepsia. Dig Dis Sci 47, 20–26 (2002). https://doi.org/10.1023/A:1013294815971

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