Abstract
The endocrine system coordinates development of the mammary gland with reproductive development and the demand of the offspring for milk. Three categories of hormones are involved. The levels of the reproductive hormones, estrogen, progesterone, placental lactogen, prolactin, and oxytocin, change during reproductive development or function and act directly on the mammary gland to bring about developmental changes or coordinate milk delivery to the offspring. Metabolic hormones, whose main role is to regulate metabolic responses to nutrient intake or stress, often have direct effects on the mammary gland as well. The important hormones in this regard are growth hormone, corticosteroids, thyroid hormone, and insulin. A third category of hormones has recently been recognized, mammary hormones. It currently includes growth hormone, prolactin, PTHrP, and leptin. Because a full-term pregnancy in early life is associated with a reduction in breast carcinogenesis, an understanding of the mechanisms by which these hormones bring about secretory differentiation may offer clues to the prevention of breast cancer.
Similar content being viewed by others
REFERENCES
R. C. Hovey, J. Trott, and B. K. Vonderhaar (2002). Establishing a framework for the functional mammary gland: From endocrinology to morphology. J.Mammary Gland Biol.Neoplasia 7:17–38.
A. T. Cowie, I. A. Forsyth, and I. C. Hart (1980). Hormonalcontrol of lactation. Monogr.Endocrinol. 1–275.
Y. J. Topper and C. S. Freeman (1980). Multiple hormone interactions in the developmental biology of the mammary gland. Physiol.Rev.60:1049–1106.
J. A. Mol, I. Lantinga-van Leeuwen, E. van Garderen, and A. Rijnberk (2000). Progestin-induced mammary growth hormone(GH) production. Adv.Exp.Med.Biol.480:71–76.
K. Lippuner, H. J. Zehnder, J. P. Casez, R. Takkinen, and P. Jaeger (1996). PTH-related protein is released intothe mother's bloodstream during lactation: Evidence for beneficial effects on maternal calcium-phosphate metabolism. J.Bone Miner.Res.11:1394–1399.
B. Woodside, A. Abizaid, and C. Walker (2000). Changes in leptin levels during lactation: Implications for lactational hyperphagia and anovulation. Horm.Behav.37:353–365.
C. V. Clevenger and T. L. Plank (1997). Prolactin as an au-tocrine/paracrine factor in breast tissue. J.Mammary GlandBiol.Neoplasia 2:59–68.
P. Ramamoorthy, R. Sticca, T. E. Wagner, and W. Y. Chen(2001). In vitro studies of a prolactin antagonist, hPRL-G129Rin human breast cancer cells. Int.J.Oncol.18:25–32.
B. K. Vonderhaar (1999). Prolactin involvement in breastcancer. Endocr.Relat.Cancer 6:389–404.
J. L. Kelsey and M. D. Gammon (1990). Epidemiology ofbreast cancer. Epidemiol.Rev.12:228–249.
D. Medina and G. H. Smith (1999). Chemical carcinogen-induced tumorigenesis in parous, involuted mouse mammary glands. J.Natl.Cancer Inst.91:967–969.
G. Thordarson, K. Van Horn, R. C. Guzman, S. Nandi, and F. Talamantes (2001). Parous rats regain high susceptibility to chemically induced mammary cancer after treatment with various mammotropic hormones. Carcinogenesis 22:1027–1033.
L. Sivaraman, S. G. Hilsenbeck, L. Zhong, J. Gay, O. M. Conneely, D. Medina, and B. W. O'Malley (2001). Early exposure of the rat mammary gland to estrogen and progesterone blocks co-localization of estrogen receptor expression and proliferation. J.Endocrinol.171:75–83.
C. Brisken (2002). Hormonal control of alveolar development and its implications for breast carcinogenesis. J.MammaryGland Biol.Neoplasia 7:49–66.
P. E. Hartmann (1973). Changes in the composition and yield of the mammary secretion of cows during the initiation of lactation. J.Endocr.59:231–247.
G. W. Robinson, R. A. McKnight, G. H. Smith, and L. Hennighausen (1995). Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development 121:2079–2090.
R. H. Martin, M.R. Glass, C. Chapman, G. D. Wilson, and K. L. Woods (1980). Human alpha-lactalbumin and hormonal factorsin pregnancy and lactation. Clin.Endocrinol.13:223–230.
M. C. Neville, J. Morton, and S. Umemora (2001). Lactogenesis: The transition from pregnancy to lactation. Pediatr.Clin.North Am.48:35–52.
H. H. Traurig (1967). Cell proliferation in the mammary gland during late pregnancy and lactation. Anat.Rec.157:489–504.
N. Normanno and F. Ciardiello (1997). EGF-related peptidesin the pathophysiology of the mammary gland. J.MammaryGland Biol.Neoplasia 2:143–151.
K. L. Troyer and D. C. Lee (2001). Regulation of mouse mammary gland development and tumorigenesis by the ERBB signaling network. J.Mammary Gland Biol.Neoplasia 6:7–21.
C. W. Daniel, S. Robinson, and G. B. Silberstein (1996). Therole of TGF-¯ in patterning and growth of the mammary ductal tree. J.Mammary Gland Biol.Neoplasia 1:331–341.
J. W. Pollard (2001). Tumour-stromal interactions: Transforming growth factor-beta isoforms and hepatocyte growthfactor/scatter factor in mammary gland ductal morphogenesis. Breast Cancer Res.3:230–237.
T. L. Wood, M. M. Richert, M. A. Stull, and M. A. Allar (2000). The insulin-like growth factors (IGFs) and IGF binding proteins in postnatal development of murine mammaryglands. J.Mammary Gland Biol.Neoplasia 5:31–42.
T. B. McFadden, R. M. Akers, and G. W. Kazmer (1987). Alpha-lactalbumin in bovine serum: Relationships with ud-derdevelopment and function. J.Dairy Sci.70:259–264.
B. K. Vonderhaar and S. E. Ziska (1989). Hormonal regulationof milk protein gene expression. Ann.Rev.Physiol.51:641–652.
R. P. Deis and C. Delouis (1983). Lactogenesis induced byovariectomy in pregnant rats and its regulation by oestrogenand progesterone. J.Steroid Biochem.18:687–690.
Y. Mizoguchi, J. Y. Kim, T. Sasaki, T. Hama, M. Sasaki, J. Enami, and S. Sakai (1996). Acute expression of the PRLreceptor gene after ovariectomy in midpregnant mouse mam-marygland. Endocrine.J.43:537–544.
Y. Mizoguchi, H. Yamaguchi, F. Aoki, J. Enami, and S. Sakai(1997). Corticosterone is required for the prolactin receptorgene expression in the late pregnant mouse mammary gland. Mol.Cell Endocrinol.132:177–183.
S. Nishikawa, R. C. Moore, N. Nonomura, and T. Oka (1994). Progesterone and EGF inhibit mouse mammary gland pro-lactinreceptor and ¯-casein gene expression. Am.J.Physiol.267:C1467–C1472.
D. D. Nguyen, A. F. Parlow, and M. C. Neville (2001). Hor-monalregulation of tight junction closure in the mouse mam-maryepithelium during the transition from pregnancy to lactation. J.Endocrinol.170:347–356.
M. E. Freeman, B. Kanyicska, A. Lerant, and G. Nagy (2000). Prolactin: Structure, function and regulation of secretion. Physiol.Rev.80:1523–1631.
Z. B. Andrews, I. C. Kokay, and D. R. Grattan (2001). Dissociation of prolactin secretion from tuberoinfundibulardopamine activity in late pregnant rats. Endocrinology 142:2719–2724.
D. J. Mellor, D. J. Flint, R. G. Vernon, and I. A. Forsyth (1987). Relationships between plasma hormone concentrations, udder development and the production of early mammary secretions in twin-bearing ewes on different planes of nutrition. Quart.J.Exp.Physiol.72:345–356.
R. De Hertogh, K. Thomas, Y. Bietlot, I. Vanderheyden, and J. Ferin (1975). Plasma levels of unconjugated estrone, estra-dioland estriol and of HCS throughout pregnancy in normalwomen. J.Clin.Endocrinol.Metab.40:93–101.
D. Tulchinsky, C. J. Hobel, E. Yeager, and J. R. Marshall(1972). Plasma estrone, estradiol, progesterone and 17-hydroxyprogesterone in human pregnancy. 1. Normal pregnancy. Am.J.Obstet.Gynecol.112:1095–1100.
L. A. Rigg, A. Lein, and S. S. Yen (1977). Pattern of increasein circulating prolactin levels during human gestation. Am.J.Obstet.Gynecol.129:454–456.
B. R. Carr, C. R. Parker Jr., J. D. Madden, P. C. MacDonald, and J. C. Porter (1981). Maternal plasma adrenocorticotropin and cortisol relationships throughout human pregnancy. Am.J.Obstet.Gynecol.139:416–422.
M. C. Neville (1983). Regulation of mammary developmentand lactation. In M. C. Neville and M. R. Neifert (eds.), Lactation: Physiology, Nutrition and Breast-feeding, PlenumPress, New York, pp. 103–140.
R. H. Martin and R. E. Oakey (1982). The role of antena-taloestrogen in post-partum human lactogenesis: Evidencefrom oestrogen-deficient pregnancies. Clin.Endocrinol.17:403–408.
J. K. Kulski, P. E. Hartmann, J. D. Martin, and M. Smith(1978). Effects of bromocriptine mesylate on the composi-tionof the mammary secretion in non-breast-feeding women. Obstet.Gynecol.52:38–42.
I. A. Forsyth and P. D. Lee (1993). Bromocriptine treatment ofperiparturient goats: Long-term suppression of prolactin andlack of effect on lactation. J.Dairy Res.60:307–317.
D. Schams (1972). Prolactin levels in bovine blood, influenced by milking manipulation, genital stimulation and oxytocin administration with specific consideration of the seasonal variations. Acta Endocrinol.71:684–696.
C. C. K. Tay, A. F. Glasier, and A. S. McNeilly (1996). Twentyfour hour patterns of prolactin secretion during lactation andthe relationship to suckling and the resumption of fertility in breast-feeding women. Hum.Reprod.11:950–955.
D. J. Flint and R. G. Vernon (1998). Effects of food restric-tionon the responses of the mammary gland and adiposetissue to prolactin and growth hormone in the lactating rat. J.Endocrinol.156:299–305.
L. J. Benedek-Jaszmann and V. Sternthal (1976). Late suppres-sionof lactation with bromocryptine. Practitioner 216:450.
H. Nagasawa and R. Yanai (1978). Mammary gland pro-lactinreceptor and pituitary prolactin secretion in lactatingmice with different lactational performance. Acta Endocrinol.88:94–98.
D. J. Flint and C. H. Knight (1997). Interactions of prolactinand growth hormone in the regulation of mamary gland function and epithelial cell survival. J.Mammary Gland Biol.Neoplasia 2:41–48.
K. L. Schwertfeger, M. M. Richer, and S. M. Anderson (2001). Mammary gland involution is delayed by activated Akt intransgenic mice. Mol.Endocrinol.15:867–881.
C. Bole-Feysot, V. Goffin, M. Edery, N. Binart, and P. A. Kelly(1998). Prolactin (PRL) and its receptor: Actions, signal trans-duction pathways and phenotypes observed in PRL receptorknockout mice. Endocr.Rev.19:225–268.
S. Cassy, M. Charlier, L. Belair, M. Guillomot, G. Charron, B. Bloch, and J. Djiane (1998). Developmental expression andlocalization of the prolactin receptor (PRL-R) gene in ewemammary gland during pregnancy and lactation: Estimationof the ratio of the two forms of PRL-R messenger ribonucleicacid. Biol.Reprod.58:1290–1296.
Z. Z. Hu, J. Meng, and M. L. Dufau (2001). Isolation andcharacterization of two novel forms of the human prolactinreceptor generated by alternative splicing of a newly identifiedexon 11. J.Biol.Chem.276:41086–41094.
C. Brisken, S. Kaur, T. E. Chavarria, N. Binart, R. L. Sutherland, R. A. Weinberg, P. A. Kelly, and C. J. Ormandy(1999). Prolactin controls mammary gland developmentvia direct and indirect mechanisms. Dev.Biol.210:96–106.
M. I. Gallego, N. Binart, G. W. Robinson, R. Okagaki, K. T. Coschigano, J. Perry, J. J. Kopchick, T. Oka, P. A. Kelly, and L. Hennighausen (2001). Prolactin, growth hormone, and epi-dermalgrowth factor activate Stat5 in different compartmentsof mammary tissue and exert different and overlapping developmental effects. Dev.Biol.229:163–175.
X. Liu, G. W. Robinson, K. U. Wagner, L. Garrett, A. Wynshaw-Boris, and L. Hennighausen (1997). Stat5a ismandatory for adult mammary gland development and lactogenesis. Genes Devel.11:179–186.
M. N. Emane, C. Delouis, P. A. Kelly, and J. Djiane (1986). Evolution of prolactin and placental lactogen receptorsin ewes during pregnancy and lactation. Endocrinology 118:695–700.
I. A. Forsyth (1994). Comparative aspects of placental lactogens: Structure and function. Exp.Clin.Endocrinol.102:244–251.
F. Talamantes and L. Ogren (1988). The placenta as an en-docrineorgan: Polypeptides. In E. Knobil and J. D. Neill (eds.),The Physiology of Reproduction, Raven Press, New York, pp. 2093–2144.
P. Gaede, D. Trolle, and H. Pedersen (1978). Extremely lowplacental lactogen hormone (hPL) values in an otherwise un-eventlfulpregnancy preceding delivery of a normal baby. ActaObstet.Gynecol.Scand.57:203–209.
P. V. Nielson, H. Pederson, and E. Kampmann (1979). Ab-senceof placental lactogen in an otherwise uneventful pregnancy. Am.J.Obstet.Gynecol.135:322–330.
A. Herman, C. Bignon, N. Daniel, J. Grosclaude, A. Gertler,and J. Djiane (2000). Functional heterodimerization of pro-lactinand growth hormone receptors by ovine placental lactogen. J.Biol.Chem.275:6295–6301.
R. W. Caron, G. A. Jahn, and R. P. Deis (1994). Lactogenicactions of different growth hormone preparations in pregnant and lactating rats. J.Endocrinol.142:535–545.
Y. N. Ilkbahar, G. Thordarson, I. G. Camarillo, and F. Talamantes (1999). Differential expression of the growthhormone receptor and growth hormone-binding protein inepithelia and stroma of the mouse mammary gland at variousphysiological stages. J.Endocrinol.161:77–87.
E. L. Gregoraszczuk, T. Milewicz, J. Kolodziejczyk, J. Krzysiek, A. Basta, K. Sztefko, S. Kurek, and J. Stachura(2001). Progesterone-induced secretion of growth hormone, insulin-like growth factor I and prolactin by human breastcancer explants. Gynecol.Endocrinol.15:251–258.
Y. Zhou, B. C. Xu, H. G. Maheshwari, L. He, M. Reed, M. Lozykowski, S. Okada, L. Cataldo, K. Coschigamo, T. E. Wagner, G. Baumann, and J. J. Kopchick (1997). Amammalianmodel for Laron syndrome produced by targeted disruptionof the mouse growth hormone receptor/binding protein gene(the Laron mouse). Proc.Natl.Acad.Sci.U.S.A.94:13215–13220.
D. L. Rimoin, G. B. Holzman, T. J. Merimee, D. Rabinowitz, A. C. Barnes, J. E. Tyson, and V. A. McKusick (1968). Lac-tationin the absence of human growth hormone. J.Clin.Endocrinol.Metab.28:1183–1188.
A. L. Rosenbloom, J. Guevara-Aguirre, R. G. Rosenfeld, and U. Francke (1999). Growth hormone receptor deficiency in Ecuador. J.Clin.Endo.Metab.84:4436–4443.
D. E. Bauman and R. G. Vernon (1993). Effects of exoge-nousbovine somatotropin on lactation. Annu.Rev.Nutr.13:437–461.
D. J. Flint and M. Gardner (1994). Evidence that growthhormone stimulates milk synthesis by direct action on themammary gland and that prolactin exerts effects on milk se-cretionby maintenance of mammary deoxyribonucleic acidcontent and tight junction status. Endocrinology 135:1119–1124.
K. M. Darcy, S. F. Shoemaker, P.-P. H. Lee, B. A. Ganis, and M. M. Ip (1995). Hydrocortisone and progesterone regulation of the proliferation, morphogenesis, and functional differentiation of normal rat mammary epithelial cells in three dimensional primary culture. J.Cell.Physiol.163:365–379.
S. Z. Haslam and G. Shyamala (1980). Progesterone receptorsin normal mammary gland: Receptor modulations in relation to differentiation. J.Cell Biol.86:730–737.
M. C. Neville and C. T. Walsh (1996). Effects of drugs on milk secretion and composition. In P. N. Bennett (ed.), Drugs andHuman Lactation, Elsevier, Amsterdam, pp. 15–45.
F. Athie, K. C. Bachman, H. H. Head, M. J. Hayen, and C. J. Wilcox (1996). Estrogen administered at final milk removalaccelerates involution of bovine mammary gland. J.Dairy Sci.79:220–226.
H. S. Jin, S. Umemora, T. Iwasaka, and R. Y. Osamura (2000). Alterations of myoepithelial cells in the rat mammary glandduring pregnancy, lactation and involution, and after estradioltreatment. Pathol.Int.50:384–391.
Z. Feng, A. Marti, B. Jehn, H. J. Altermatt, G. Chicaiza, and R. Jaggi (1995). Glucocorticoid and progesterone inhibit in-volutionand programmed cell death in the mouse mammarygland. J.Cell Biol.131:1095–1103.
N. F. Butte, J. M. Hopkinson, J. K. Moon, N. Mehta, and E. O. Smith (1999). Adjustments in energy expenditure andsubstrate utilization during late pregnancy and lactation. Am.J.Clin.Nutr.69:299–307.
K. L. Blaxter, E. P. Reineke, E. S. Crampton, and W. E. Petersen (1949). The role of thyroidal materials and of syn-theticgoitrogens in animal production and an appraisal of their practical use. J.Anim.Sci.8:307–352.
A. V. Capuco, S. Kahl, L. J. Jack, J. O. Bishop, and H. Wallace(1999). Prolactin and growth hormone stimulation of lactationin mice requires thyroid hormones. Proc.Soc.Exp.Biol.Med.221:345–351.
S. E. Ziska, M. Bhattacharjee, R. L. Herber, P. K. Qasba, and B. K. Vonderhaar (1988). Thyroid hormone regulation ofalpha-lactalbumin: Differential glycosylation and messengerribonucleic acid synthesis in mouse mammary glands. Endocrinology 123:2242–2248.
Y. Iwatani, N. Amino, O. Tanizawa, H. Mori, M. Kawashima,Y. Yabu, and K. Miyai (1987). Decrease of free thyroxin inserum of lactating women. Clin.Chem.33:1217–1219.
G. A. van Haasteren, H. van Toor, W. Klootwijk, B. Handler,E. Linkels, P. van der Schoot, J. van Ophemert, F. H. DeJong,T. J. Visser, and W. J. de Greef (1996). Studies on the role ofTRHand corticosterone in the regulation of prolactin and thy-rotrophinsecretion during lactation. J.Endocrinol.148:325–336.
L. J. Jack, S. Kahl, D. L. St Germain, and A. V. Capuco (1994). Tissue distribution and regulation of 50-deiodinase processesin lactating rats. J.Endocrinol.142:205–215.
L. Navarro, A. Landa, C. Valverde-R, and C. Aceves (1999). Mammary gland type I iodthyronine deiodinase is encoded bya short messenger ribonucleic acid. Endocrinology 138:4248–4254.
L. Quevedo-Corona, M. Franco-Colin, M. Caudillo-Romero,J. Pacheco-Rosado, S. Zamudio-Hernandez, and R. Racotta(2000). 3,5,30-Triiodothyronine administered to rat dams dur-inglactation increases milk yield and triglyceride concentra-tionand hastens pups growth. Life Sci.66:2013–2121.
S. R. Davis, R. J. Collier, J. P. McManamara, H. H. Head,and W. Sussman (1988). Effects of thyroxine and growth hor-monetreatment of dairy cows on milk yield, cardiac outputand mammary blood flow. J.Anim.Sci.66:70–79.
F. Peters, J. Schulze-Tollert, and W. Schuth (1991). Thyrotrophin-releasing hormone—A lactation-promotingagent? Br.J.Obstet.Gynecol.98:880–885.
S. Y. Kyriakou and N. J. Kuhn (1973). Lactogenesis in the diabetic rat. J.Endocrinol.59:199–200.
K. Hove (1978). Maintenance of lactose secretion during acute insulin deficiency in lactating goats. Acta Physiol.Scand.103:173–179.
M. C. Neville and M. F. Picciano (1997). Regulation of milklipid synthesis and composition. Ann.Rev.Nutr.17:159–184.
R. A. DeFronzo, J. D. Tobin, and R. Andres (1979). The glu-coseclamp technique. Amethod for quantifying insulin secre-tionand resistance. Am.J.Physiol.237:E214–E223.
J. M. Griinari, M. A. McGuire, D. A. Dwyer, D. E. Bauman, D. M. Barbano, and W. E. House (1997). The role of insulin inthe regulation of milk protein synthesis in dairy cows. J.DairySci.80:2361–2371.
M. C. Neville, V. Sawicki, and W. W. Hay Jr. (1993). Effect offasting, elevated plasma glucose and plasma insulin concentration son milk secretion in women. J.Endocrinol.139:165–173.
W. R. Crowley and W. E. Armstrong (1992). Neurochemi-calregulation of oxytocin secretion in lactation. Endocr.Rev.13:33–65.
W. S. Young III, E. Shepard, J. Amico, L. Hennighausen, K. U. Wagner, M. E. LaMarca, C. McKinney, and E. I. Ginns (1996). Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition. J.Neuroendocrinol.8:847–853.
G. Gimpl and F. Fahrenholz (2001). The oxytocin receptor system: Structure, function and regulation. Physiol.Rev 81:629–683.
R. M.Akers and A. M.Lefcourt (1982). Milking-and suckling-inducedsecretion of oxytocin and prolactin in parturient dairycows. Horm.Behav.16:87–93.
A. S. McNeilly, I. C. Robinson, M. J. Houston, and P. W. Howie(1983). Release of oxytocin and prolactin in response to suck-ling. Br.Med.J.Clin.Res.286:257–259.
M. S. Soloff, M. Alexandrova, and M. J. Fernstrom (1979). Oxytocin receptors: Triggers for parturition and lactation? Science 204:1313–1315.
A. Sapino, L. Macri, L. Tonda, and G. Bussolati (1993). Oxy-tocinenhances myoepithelial cell differentiation and prolifer-ationin the mouse mammary gland. Endocrinology 133:838–842.
J. A. Amico, A. Thomas, R. S. Crowley, and L. A. Burmeister(1998). Concentrations of leptin in the serum of pregnant,lactating, and cycling rats and of leptin messenger ribonucleicacid in rat placental tissue. Life Sci.63:1387–1395.
H. J. Kalkwarf (1999). Hormonal and dietary regulation of changes in bone density during lactation and after weaning in women. J.Mammary Gland Biol.Neoplasia 4:319–329.
P. Martyn and I. A. Hansen (1981). Initiation of lipogenic en-zymeactivities in rat mammary glands. Biochem.J.198:187–192.
R. W. Mellenberger and D. E. Bauman (1974). Metabolicadaptations during lactogenesis: Fatty acid synthesis in rab-bitmammary tissue during pregnancy and lactation. Biochem.J 138:373–379.
M. Peaker and C. J. Wilde (1996). Feedback control of milksecretion from milk. J.Mammary Gland Biol.Neoplasia 1:307–315.
R. D. Burgoyne and C. J. Wilde (1994). Control of secre-toryfunction in mammary epithelial cells. Cell.Signal.6:607–616.
K. A. Hammond, K. C. Lloyd, and J. Diamond (1996). Is mam-maryoutput capacity limiting to lactational performance inmice. J.Exp.Biol.199:337–349.
A. W. Bell and D. E. Bauman (1997). Adaptations of glu-cosemetabolism during pregnancy and lactation. J.MammaryGland Biol.Neoplasia 2:265–278.
M. C. Neville (1995). Volume and caloric density of human milk. In R. G. Jensen (ed.), Handbook of Milk Composition, Academic Press, San Diego, pp. 101–113.
C. J. Wilde, C. H. Knight, and D. J. Flint (1999). Controlof milk secretion and apoptosis during mammary involution. J.Mammary Gland Biol.Neoplasia 4:129–136.
A. Marti, Z. W. Feng, H. J. Altermatt, and R. Jaggi (1997). Milk accumulation triggers apoptosis of mammary epithelialcells. Eur.J.Cell Biol.73:158–165.
E. Tonner, G. J. Allan, and D. J. Flint (2000). Hormonal controlof plasmin and tissue-type plasminogen activator activity in ratmilk during involution of the mammary gland. J.Endocrinol.167:265–273.
I. H. Russo, M. Koszalka, and J. Russo (1990). Humanchorionic gonadotropin and rat mammary cancer prevention. J.Natl.Cancer Inst.82:1286–1289.
L. Sivaraman, O. M. Conneely, D. Medina, and B. W. O'Malley(2001). p53 is a potential mediator of pregnancy and hormone-inducedresistance to mammary carcinogenesis. Proc.Natl.Acad.Sci.U.S.A.98:12379–12384.
H. P. Gardner, S. I. Ha, C. Reynolds, and L. A. Chodosh (2000). The caM kinase, Pnck, is spatially and temporally regulatedduring murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer. Cancer Res.60:5571–5577.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Neville, M.C., McFadden, T.B. & Forsyth, I. Hormonal Regulation of Mammary Differentiation and Milk Secretion. J Mammary Gland Biol Neoplasia 7, 49–66 (2002). https://doi.org/10.1023/A:1015770423167
Issue Date:
DOI: https://doi.org/10.1023/A:1015770423167