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Mechanism of doxorubicin-induced cell death and expression profile analysis

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Abstract

We characterized doxorubicin-induced cell death in gastric cancer cells. It induced apoptotic phenotypes including poly(ADP-ribose) polymerase cleavage, and activation of caspases. By using cDNA microarray analysis, we identified 18 genes that are induced by doxorubicin in at least four of nine gastric cancer cell lines.

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Lee, S., Baek, M., Kim, HY. et al. Mechanism of doxorubicin-induced cell death and expression profile analysis. Biotechnology Letters 24, 1147–1151 (2002). https://doi.org/10.1023/A:1016174800956

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  • DOI: https://doi.org/10.1023/A:1016174800956

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