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A radiation hybrid framework map of bovine chromosome 13

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Abstract

In this paper we present a 5000-rad radiation hybrid framework map of bovine chromosome 13 (BTA13) containing 13 loci, including five conserved genes and eight polymorphic microsatellites. All framework markers are ordered with odds greater than 1000:1. Furthermore, we present a comprehensive map of BTA13 integrating 11 genes and 16 microsatellites. The proposed order is in general agreement with the recently published medium-density linkage maps. A model of five blocks of genes with conserved order between human, mouse and cattle is presented.

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References

  • Barendse W, Armitage SM, Kossarek LM et al. (1994) A genetic linkage map of the bovine genome. Nat Genet 6: 227–235.

    Article  PubMed  Google Scholar 

  • Barendse W, Vaiman D, Kemp SJ et al. (1997) A medium-density genetic linkage map of the bovine genome. Mammalian Genome 8: 21–28.

    Article  PubMed  Google Scholar 

  • Barrett JH (1992) Genetic mapping based on radiation hybrid data. Genomics 13: 95–103.

    Article  PubMed  Google Scholar 

  • Bishop MD, Kappes SM, Keele JW et al. (1994) A genetic linkage map for cattle. Genetics 136: 619–639.

    PubMed  Google Scholar 

  • Boehnke M, Lange K, Cox CR (1991) Statistical methods for multipoint radiation hybrid mapping. Am J Hum Genet 49: 1174–1188.

    PubMed  Google Scholar 

  • Cai L, Taylor JF, Wing RA, Gallagher DS, Woo S-S, Davis SK (1995) Construction and characterization of a bovine bacterial artificial chromosome library. Genomics 29: 413–425.

    Article  PubMed  Google Scholar 

  • Ceccherini I, Romeo G, Lawrence S et al. (1990) Construction of a map of chromosome 16 by using radiation hybrids. Proc Nat Acad Sci USA 89: 104–108.

    Google Scholar 

  • Chowdhary BP, Frönicke L, Gustavsson I, Scherthan H (1996) Comparative analysis of the cattle and human genomes: detection of ZOO-FISH and gene mapping-based chromosomal homologies. Mammalian Genome 7: 297–302.

    Article  PubMed  Google Scholar 

  • Collins FS (1995) Positional cloning moves from perditional to traditional. Nature Genet 9: 347–350.

    Article  PubMed  Google Scholar 

  • Dib C, Faure S, Fizames C et al. (1996) A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380: 152–154.

    Article  PubMed  Google Scholar 

  • Dietz AB, Neibergs HL, Womack JE (1992) Assignment of eight loci to bovine syntenic groups by use of PCR: extension of a comparative gene map. Mammalian Genome 3}: 106–11

    Article  PubMed  Google Scholar 

  • Don RH, Cox PT, Wainwright BJ, Baker K, Mattick JS (1991) ‘Touchdown’ PCR to circumvent spurious priming during gene amplification. Nucleic Acids Res 19: 4008.

    PubMed  Google Scholar 

  • Gallagher DS, Gibbs LS, Shafer JB, Womack JE (1992) Somatic cell mapping of bovine EC-SOD and SOD1L loci. Genomics 12: 610–612.

    Article  PubMed  Google Scholar 

  • Gao Q (1996) Comparative mapping of the bovine genome: A multi-method approach targeting three gene families and bovine chromosome 7. Ph.D. Thesis, College Station, Texas: Texas A&M University.

  • Gao Q, Womack JE (1993) Somatic cell mapping of five genes in cattle. Texas Genetics Society 20th annual meeting and the 4th meeting of TEXGENE, 21.

  • Gao Q, Lei L, Womack JE (1997) Assignment of the casein kinase II gene family to cattle chromosomes. Animal Genet 28: 146–149.

    Article  PubMed  Google Scholar 

  • Goss SJ, Harris H (1975) New method for mapping genes in human chromosomes. Nature 255: 680–684.

    Article  PubMed  Google Scholar 

  • Hayes H (1995) Chromosome painting with human chromosome-specific DNA libraries reveals the extent and distribution of conserved segments in bovine chromosomes. Cytogene Cell Genet 71: 168–174.

    Google Scholar 

  • Johansson M, Ellegren H, Andersson L (1995) Comparative mapping reveals extensive linkage conservation-but with gene order rearrangements-between the pig and human genomes. Genomics 25: 682–690.

    Article  PubMed  Google Scholar 

  • Jones HB (1996) Hybrid selection as method of increasing mapping power for radiation hybrids. Genome Res 6: 761–769.

    PubMed  Google Scholar 

  • Kappes SM, Keele JW, Stone RT et al. (1997) A second-generation linkage map of the bovine genome. Genome Res 7: 235–249.

    PubMed  Google Scholar 

  • Lange K, Boehnke M, Cox DR, Lunetta KL (1995) Statistical methods for polyploid radiation hybrid mapping. Genome Res 5: 136–150.

    PubMed  Google Scholar 

  • Lawrence S, Morton NE, Cox DR (1991) Radiation hybrid mapping. Proc Natl Acad Sci USA 88: 7477–7480.

    PubMed  Google Scholar 

  • Lenestra JA, van Boxtel JAF, Zwaagstra KA, Schwerin M (1993) Short interspersed nuclear element (SINE) sequences in the bovidae. Animal Genet 24: 33–39.

    PubMed  Google Scholar 

  • Lunetta KL, Boehnke M, Lange K, Cox DR (1995) Experimental design and error detection for polyploid radiation hybrid mapping. Genome Res 5: 151–163.

    PubMed  Google Scholar 

  • Ma RZ, Beever JE, Da T et al. (1996) A male linkage map of the cattle (Bos taurus) genome. J Hered 87: 261–271.

    PubMed  Google Scholar 

  • O'Brien SJ, Womack JE, Lyons LA, Moore KJ, Jenkins NA, Copeland NG (1993) Anchored reference loci for comparative genome mapping in mammals. Nature Genet 3: 103–112.

    Google Scholar 

  • Raeymaekers P, Van Zand K, Jun L et al. (1995) A radiation hybrid map with 60 loci covering the entire short arm of chromosome 12. Genomics 29: 170–178.

    Article  PubMed  Google Scholar 

  • Richard III CW, Withers DA, Meeker TC et al. (1991) A radiation hybrid map of the proximal long arm of human chromosome 11 containing the multiple endocrine neoplasia type I (MEN-I) and bcl-I disease loci. Am J Hum Genet 49: 1189–1196.

    PubMed  Google Scholar 

  • Schläpfer J, Kata SR, Amarante MRV, Womack JE (1997a) Syntenic assignment of thrombomodulin (THBD) and phos-phatidylinositol-specific phospholipase C (PLC-II) to bovine chromosome 13. Animal Genet 58: 308–309.

    Google Scholar 

  • Schläpfer J, Gallagher Jr. DS, Burzlaff JD et al. (1997b) Comparative mapping of bovine chromosome 13 by fluorescence in situ hybridization. Animal Genet (in press).

  • Sefton L, Arnaud D, Goodfellow PN, Simmler MC, Avner P (1992) Characterization of the central region containing the X-inactivation center and terminal region of the mouse X chromosome using irradiation and fusion gene transfer hybrids. Mamm Genome, 2: 2131.

    Google Scholar 

  • Solinas-Toldo S, Lengauer C, Fries R (1995) Comparative genome map of human and cattle. Genomics 27: 489–496.

    Article  PubMed  Google Scholar 

  • Threadgill D, Womack JE (1991) Mapping HSA10 homologous loci in cattle. Cytogenet Cell Genet 57: 123–126.

    PubMed  Google Scholar 

  • Walter MA, Goodfellow PN (1993) Radiation hybrids: irradiation and fusion gene transfer. Trends Genet 9: 352–356.

    Article  PubMed  Google Scholar 

  • Walter MA, Spillett DJ, Thomas P, Weissenbach J, Goodfellow PN (1994) A method for constructing radiation hybrid maps of whole genomes. Nature Genet 7: 22–28.

    Article  PubMed  Google Scholar 

  • Warrington JA, Bailey SK, Armstrong E et al. (1992) A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5. Genomics 13: 803–808.

    Article  PubMed  Google Scholar 

  • Womack JE, Moll YD (1986) Gene map of the cow: conservation of linkage with mouse and man. J Hered 77: 2–7.

    PubMed  Google Scholar 

  • Womack JE, Kata SR (1995) Bovine genome mapping: evolutionary inference and the power of comparative genomics. Current Opin Genet Dev 5: 725–733.

    Article  Google Scholar 

  • Womack JE, Dietz AB, Gallagher DS et al. (1991) Assignment of 47 additional comparative anchor loci to the bovine synteny map. Cytogenet Cell Genet 58: 2132.

    Google Scholar 

  • Womack JE, Johnson JS, Owens EK, Rexroad III CE, Schläpfer J, Yang Y (1997) A whole genome radiation hybrid panel for bovine genome mapping. Mamm Genome (in press).

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Authors and Affiliations

  1. Institute of Animal Breeding, University of Berne, Bremgartenstrasse 109a, CH-3012, Berne, Switzerland

    J. Schlapfer

  2. Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas, 77843, USA

    Y. Yang, C. Rexroad III & J. E. Womack

Authors
  1. J. Schlapfer
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  2. Y. Yang
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  3. C. Rexroad III
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  4. J. E. Womack
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Schlapfer, J., Yang, Y., Rexroad III, C. et al. A radiation hybrid framework map of bovine chromosome 13. Chromosome Res 5, 511–519 (1997). https://doi.org/10.1023/A:1018485401403

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