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Decreases in Plasma Aβ1-40 Levels with Aging in Non-Demented Elderly with ApoE-ε4 Allele

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Abstract

This report examines plasma amyloid β proteins Aβ40 and Aβ42 and apolipoprotein E (apoE) levels and their relationships with age in non-demented older adults with (N = 32) or without the apoE-ε4 allele (N = 94). Aβ levels did not differ between the groups whereas the ε4 allele was associated with a significant reduction in plasma apoE. In subjects with the ε4 allele, increasing age was associated with significant reduction in plasma Aβ40. Subjects without the ε4 allele showed a significant positive correlation between Aβ40 and Aβ42 levels. There was also a significant correlation between plasma Aβ40 and apoE levels in all subjects.

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Pomara, N., Shao, B., Wisniewski, T. et al. Decreases in Plasma Aβ1-40 Levels with Aging in Non-Demented Elderly with ApoE-ε4 Allele. Neurochem Res 23, 1563–1566 (1998). https://doi.org/10.1023/A:1020936222286

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  • DOI: https://doi.org/10.1023/A:1020936222286

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