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Smoking and non-Hodgkin's lymphoma: a case–control study in the Rhône-Alpes region of France

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Abstract

Objective: To study the relation between smoking and non-Hodgkin/s lymphoma (NHL), in the Rhône-Alpes region of France. Methods: We conducted a hospital-based case–control study that included 180 cases of NHL and 360 age-, gender-matched hospital controls. Matched univariable and multivariable logistic regression models were used for analysis. Results: For the whole study population as well as for men, smoking does not elevate the risk of NHL. However, the risk of NHL is higher for women who currently smoke compared to women who have never smoked (odds ratio [OR] = 2.40, 95% confidence interval [95% CI] = 1.19–4.84). Among ever smokers, the OR of NHL is 5.04 (95% CI = 1.40–18.12) for women who have smoked for more than 30 years compared with those who have never smoked. Similarly, women who started to smoke before the age of 20 years compared with women who have never smoked are at greater risk of developing NHL (OR = 2.40, 95% CI = 0.99–5.85). In the total population (women and men), smoking may be associated with one histologic subtype, follicular NHL with an adjusted OR for the current smokers compared to subjects having never smoked of 3.20, 95% CI = 0.79–12.97. Conclusions: In spite of the small number of subjects in the subgroups, a relation is observed between smoking and NHL among women, but not men, and in the total population a relation is suggested between smoking and follicular NHL.

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Authors and Affiliations

  1. International Agency for Research on Cancer, 150 cours Albert Thomas, 69378, Lyon cedex 8, France

    Hervé Besson, Philippe Renaudier, Ray M. Merrill & Annie J. Sasco

  2. Unité d'Hémovigilance, Hôpital de la Croix-Rousse, 103 grande rue de la Croix-Rousse, 69317, Lyon cedex 4, France

    Philippe Renaudier

  3. Service d'Hématologie, Hôpital Edouard Herriot, 5 place d'Arsonval, 69437, Lyon cedex 3, France

    Philippe Renaudier

  4. Department of Health Science, Brigham Young University, Provo, Utah, USA

    Ray M. Merrill

  5. Service d'Hématologie, Centre Hospitalier Lyon Sud, 165 chemin du grand revoyet, 69495, Pierre-Bénite cedex, France

    Bertrand Coiffier

  6. Département de cancérologie médicale, Centre Léon Bérard, 28 rue Laennec, 69008, Lyon, France

    Catherine Sebban

  7. Laboratoire d'Epidémiologie et Santé Publique, Université Claude Bernard Lyon I, 8 avenue Rockefeller, 69373, Lyon cedex 8, France

    Jacques Fabry

  8. Unité 271, Institut National de la Santé et de la Recherche Médicale, 151 cours Albert Thomas, 69003, Lyon, France

    Jacques Fabry & Christian Trepo

  9. Service d'Hépato-gastro-entérologie, Hôpital de l'Hôtel-Dieu, 1 place de l'hôpital, 69288, Lyon cedex 2, France

    Christian Trepo

  10. Director of Research, Institut National de la Santé et de la Recherche Médicale, Lyon, France

    Annie J. Sasco

Authors
  1. Hervé Besson
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  2. Philippe Renaudier
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  3. Ray M. Merrill
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  4. Bertrand Coiffier
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  5. Catherine Sebban
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  6. Jacques Fabry
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  7. Christian Trepo
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  8. Annie J. Sasco
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Correspondence to Annie J. Sasco.

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Besson, H., Renaudier, P., Merrill, R.M. et al. Smoking and non-Hodgkin's lymphoma: a case–control study in the Rhône-Alpes region of France. Cancer Causes Control 14, 381–389 (2003). https://doi.org/10.1023/A:1023978730962

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