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Membrane Phospholipid Alterations In Alzheimer's Disease: Deficiency of Ethanolamine Plasmalogens

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Abstract

The ethanolamine plasmalogens are decreased whereas serine glycerophospholipids are significantly increased in plasma membrane phospholipid in affected regions of brain in Alzheimer's disease. This may be due to stimulation of Ca2+-independent plasmalogen-selective phospholipase A2, which was recently discovered in brain. This phospholipase A2 differs from other Ca2+-independent phospholipases A2 in response to ATP and various inhibitors. It may be responsible for excess release of arachidonic acid and accumulation of prostaglandins and lipid peroxides in AD. Accumulation of the above lipid metabolites due to abnormal receptor function and signal transduction may contribute to neurodegeneration in AD.

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Authors and Affiliations

  1. Department of Medical Biochemistry, The Ohio State University, Columbus, Ohio, 43210

    Akhlaq A. Farooqui & Lloyd A. Horrocks

  2. Laboratory of Neurosciences, National Institute on Aging, Building 10, Room 6C103, Bethesda, Maryland, 20892

    Stanley I. Rapoport

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  1. Akhlaq A. Farooqui
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  2. Stanley I. Rapoport
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  3. Lloyd A. Horrocks
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Farooqui, A.A., Rapoport, S.I. & Horrocks, L.A. Membrane Phospholipid Alterations In Alzheimer's Disease: Deficiency of Ethanolamine Plasmalogens. Neurochem Res 22, 523–527 (1997). https://doi.org/10.1023/A:1027380331807

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