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Diet and premenopausal bilateral breast cancer: A case-control study

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Abstract

We investigated associations between diet and premenopausal bilateral breast cancer in a familial matched case-control study. We studied 140 cases from population-based registries in Los Angeles County (California) and Connecticut, and from the major hospitals in the southern parts of the Province of Quebec. Unaffected sisters of the cases served as matched controls (222 total). Dietary intake were assessed with a food frequency questionnaire. Total fat, monounsaturated fat, polyunsaturated fat, oleic acid, and linoleic acid intake was inversely associated with premenopausal bilateral breast cancer risk. Consumption of carbohydrates (and sweetened beverages) was associated with an increased risk. We observed no associations for dietary fiber, antioxidants, or major food groupings, but we did observe inverse associations for intake of low fat dairy products and tofu. These findings suggest that monounsaturated and polyunsaturated fats, as well as soy foods, might reduce the risk of premenopausal bilateral breast cancer.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatics, Case Western Reserve University, Cleveland, Ohio, USA

    John S. Witte

  2. Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA

    Giske Ursin, Annali Paganini-Hill & Robert W. Haile

  3. Department of Epidemiology, Institut Armand Frappier, Quebec, Canada

    Jack Siemiatycki

  4. Applied Medical Sciences, University of Southern Maine, Portland, Maine, USA

    W. Douglas Thompson

Authors
  1. John S. Witte
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  2. Giske Ursin
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  3. Jack Siemiatycki
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  4. W. Douglas Thompson
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  5. Annali Paganini-Hill
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  6. Robert W. Haile
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Witte, J.S., Ursin, G., Siemiatycki, J. et al. Diet and premenopausal bilateral breast cancer: A case-control study. Breast Cancer Res Treat 42, 243–251 (1997). https://doi.org/10.1023/A:1005710211184

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