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Mutator genes—pacemakers of evolution

Abstract

Initially a genetic oddity, male recombination in Drosophila melanogaster is now being viewed as a means of detecting mutator activity and chromosome breakage in hybridising populations and is causing us to reconsider the source and rate at which genetic variability may be generated in nature.

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References

  1. Green, M. M. in The Genetics and Biology of Drosophila, 1 b (eds Ashburner, M. & Novitski, E.) 929–946 (Academic, London, 1976).

    Google Scholar 

  2. Hiraizumi, Y. Proc. natn. Acad. Sci. U.S.A. 68, 268–270 (1971).

    Article  ADS  CAS  Google Scholar 

  3. Voelker, R. A. Mutat. Res. 22, 265–276 (1974).

    Article  CAS  PubMed  Google Scholar 

  4. Waddle, F. R. & Oster, I. I. J. Genet. 61, 177–183 (1974).

    Article  Google Scholar 

  5. Yamaguchi, O. & Mukai, T. Genetics 78, 1209–1221 (1974).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Kidwell, M. G. & Kidwell, J. F. Nature 253, 755–756 (1975).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Woodruff, R. C. & Thompson, J. N., Jr Heredity 38, 291–307 (1977).

    Article  Google Scholar 

  8. Cardellino, R. A. & Mukai, T. Genetics 80, 567–583 (1975).

    PubMed Central  Google Scholar 

  9. Sved, J. A. Genetics 77, s64 (1974).

    Google Scholar 

  10. Sved, J. A. Aust. J. biol. Sci. 29, 375–388 (1976).

    Article  CAS  PubMed  Google Scholar 

  11. Yannopoulos, G. & Pelecanos, M. Genet. Res., Camb. 29, 231–238 (1977).

    Article  Google Scholar 

  12. Green, M. M. Proc. natn. Acad. Sci. U.S.A. 74, 3490–3493 (1977).

    Article  ADS  CAS  Google Scholar 

  13. Yamaguchi, O. Mutat. Res. 34, 389–406 (1976).

    Article  CAS  PubMed  Google Scholar 

  14. Golubovsky, M. D., Ivanov, Yu. N. & Green, M. M. Proc. natn. Acad. Sci. U.S.A. 74, 2973–2975 (1977).

    Article  ADS  CAS  Google Scholar 

  15. Moriwaki, D. & Tobari, Y. N. in Handbook of Genetics, 3 (ed. King, R. C.) 513–535 (Plenum, New York, 1975).

    Google Scholar 

  16. Hinton, C. W. Genetics 66, 663–676 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Woodruff, R. C. & Bortolozzi, J. Heredity 37, 295–298 (1976).

    Article  CAS  PubMed  Google Scholar 

  18. Philip, U. Nature 153, 223 (1944).

    Article  ADS  Google Scholar 

  19. Kikkawa, H. Cytologia 6, 190–194 (1935).

    Article  Google Scholar 

  20. Franca, Z. M., Da Cunha, A. B. & Garrido, M. C. Heredity 23, 199–204 (1968).

    Article  CAS  PubMed  Google Scholar 

  21. Muller, H. J. Am. Nat. 50, 284–305 (1916).

    Article  Google Scholar 

  22. Bridges, C. B. & Morgan, T. H. Carnegie Inst. Washington, Publ. 278, 125–304 (1919).

    Google Scholar 

  23. Slatko, B. & Hiraizumi, Y. Genetics 75, 643–649 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Hiraizumi, Y. Genetics 87, 83–93 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Kidwell, M. G. & Kidwell, J. F. Genetics 84, 333–351 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Hartl, D. L. & Hiraizumi, Y. in The Genetics and Biology of Drosophila 1 b (eds Ashburner, M. & Novitski, E.) 615–666 (Academic, London, 1976).

    Google Scholar 

  27. Woodruff, R. C. & Thompson, J. N. Jr Genetics 80, s86 (1975).

    Google Scholar 

  28. Kidwell, M. G. & Kidwell, J. F. J. Hered. 66, 367–375 (1975).

    Article  CAS  PubMed  Google Scholar 

  29. Kidwell, M. G., Kidwell, J. F. & Ives, P. T. Mutat. Res. 42, 89–98 (1977).

    Article  Google Scholar 

  30. Sved, J. A. Nature 241, 453–454 (1973).

    Article  ADS  CAS  PubMed  Google Scholar 

  31. Kidwell, M. G. Genet. Res., Camb. 30, 77–88 (1977).

    Article  CAS  Google Scholar 

  32. Yamaguchi, O., Cardellino, R. A. & Mukai, T. Genetics 83, 409–422 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  33. Kidwell, M. G., Kidwell, J. F. & Sved, J. A. Genetics 86, 813–833 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Thompson, J. N. Jr. & Woodruff, R. C. Heredity 40, 153–157 (1978).

    Article  PubMed  Google Scholar 

  35. Henderson, S. A., Woodruff, R. C. & Thompson, J. N., Jr Genetics 88, 93–107 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Thompson, J. N., Jr, Woodruff, R. C. & Schaefer, G. B. Genetica (in the press).

  37. Thompson, J. N., Jr, Woodruff, R. C. & Schaefer, G. B. Genetics 86, s64–s65 (1977).

    Google Scholar 

  38. Hiraizumi, Y., Slatko, B., Langley, C. & Nill, A. Genetics 73, 439–444 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  39. Becker, H. J. in The Genetics and Biology of Drosophila 1c (eds Ashburner, M. & Novitski, E.) 1019–1087 (Academic, London, 1976).

    Google Scholar 

  40. Slatko, B. & Hiraizumi, Y. Genetics 81, 313–324 (1975).

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Sochacka, J. H. N. & Woodruff, R. C. Nature 262, 287–289 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  42. Hellack, J. J., Thompson, J. N. Jr, Woodruff, R. C. & Hisey, B. N. Experientia 34, 447 (1978).

    Article  Google Scholar 

  43. Ehrman, L. & Kernaghan, R. P. J. Hered. 62, 67–71 (1971).

    Article  CAS  PubMed  Google Scholar 

  44. Nichols, W. W. A. Rev. Microbiol. 24, 479–500 (1970).

    Article  CAS  Google Scholar 

  45. Levitan, M. & Williamson, D. L. Genetics 52, 456 (1965).

    Google Scholar 

  46. Picard, G. Genetics 83, 107–123 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  47. Kearsey, M. J., Williams, W. R., Allen, P. & Coulter, F. Heredity 38, 109–115 (1977).

    Article  Google Scholar 

  48. Bucheton, A., Lavige, J. M., Picard, G. & L'Heritier, P. Heredity 36, 305–314 (1976).

    Article  CAS  PubMed  Google Scholar 

  49. Novitski, E. Genetics 32, 526–534 (1947).

    CAS  PubMed  PubMed Central  Google Scholar 

  50. Malogolowkin, C. Genetics 43, 274–286 (1958).

    CAS  PubMed  PubMed Central  Google Scholar 

  51. Stalker, H. D. Genetics 46, 177–202 (1961).

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Faulhaber, S. H. Genetics 56, 189–213 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  53. Leventhal, E. J. invert. Path. 11, 170–183 (1968).

    Article  CAS  Google Scholar 

  54. Sandler, L., Lindsley, D. L., Nicoletti, B. & Trippa, G. Genetics 60, 525–558 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  55. Minamori, S., Inoue, Y., Ito, K. & Shimizu, A. Jap. J. Genet. 52, 87–93 (1977).

    Article  Google Scholar 

  56. Williams, G. C. Adaptation and Natural Selection (Princeton University Press, 1966).

    Google Scholar 

  57. Sturtevant, A. H. Proc. natn. Acad. Sci. U.S.A. 25, 308–310 (1939).

    Article  ADS  CAS  Google Scholar 

  58. Yen, J. H. & Barr, A. R. Nature 232, 657–658 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  59. Wright, J. W. & Pal, R. Genetics of Insect Vectors of Disease (Elsevier, New York, 1967).

    Google Scholar 

  60. Hennen, S. Devl Biol. 6, 133–183 (1963).

    Article  CAS  Google Scholar 

  61. Newman, L. J. Genetics 50, 272 (1964).

    Google Scholar 

  62. Stutz, H. C. Can. J. Genet. Cytol. 18, 105–109 (1976).

    Article  Google Scholar 

  63. Ives, P. T. Evolution 4, 236–252 (1950).

    Article  Google Scholar 

  64. Spencer, W. P. Am. Nat. 69, 223–238 (1935).

    Article  Google Scholar 

  65. Neel, J. V. Genetics 27, 519–536 (1942).

    CAS  PubMed  PubMed Central  Google Scholar 

  66. Demerec, M. Genetics 22, 469–478 (1937).

    CAS  PubMed  PubMed Central  Google Scholar 

  67. Novitski, E. & Hanks, G. D. Nature 190, 989–900 (1961).

    Article  ADS  CAS  PubMed  Google Scholar 

  68. Slatko, B. Mutat. Res. 36, 387–390 (1976).

    Article  CAS  PubMed  Google Scholar 

Download references

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Thompson, J., Woodruff, R. Mutator genes—pacemakers of evolution. Nature 274, 317–321 (1978). https://doi.org/10.1038/274317a0

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