Abstract
RELATIVE protection against Plasmodium falciparum malaria afforded to heterozygous carriers of the sickle-cell gene is now the accepted mechanism for the high frequency of the gene in areas where malaria is (or was) common1–3. However, the cellular mechanisms whereby Hb S protects the red cell against the malarial parasite are still not fully understood. We have compared the rates of invasion and growth of P. falciparum in normal red cells and in those of individuals with the sickling disorders, in both aerobic conditions and conditions of reduced oxygen tension. As a result of these studies, we suggest a possible mechanism for the protection of sickle-cell heterozygotes against P. falciparum malaria.
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References
Allison, A. C. Br. med. J. 1, 290 (1954).
Raper, A. B. Br. med. J. 1, 1186 (1955).
Luzzatto, L. Bull. World Hlth Org. 50, 195 (1974).
Pasvol, G., Weatherall, D. J. & Wilson, R. J. M. Nature, 270, 171 (1977).
Pasvol, G., Wilson, R. J. M., Smalley, M. E. & Brown, J. Ann. trop. Med. Parasit. 72, 87 (1978).
Messer, M. J., Hahn, J. A. & Bradley, T. B. Proc. Symp. Molecular and Cellular Aspects of Sickle Cell Disease (eds Hercules, J. et al.), 225 (U.S. Dept of Health, Education and Welfare, National Institutes of Health, 1975).
Siddiqui, W. A. & Schnell, J. V. Proc. Helminth. Soc. Wash. 39, 204 (1972).
Maegraith, B. G. & Fletcher, K. A. Adv. Parasit. 10, 49 (1972).
Lambotte-Legrand, J. & Lambotte-Legrand, C. Ann. Soc. Belge de Med. trop. 31, 207 (1951).
Raper, A. B. Br med. J. 1, 965 (1956).
Milner, P. F. Clin. Haemat. 3, 289 (1974).
Luzzatto, L., Nwachuku-Jarrett, E. S. & Reddy, S. Lancet, i, 319 (1970).
Friedman, M. J. Proc. natn. Acad. Sci. U.S.A. 75, 1994 (1978).
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PASVOL, G., WEATHERALL, D. & WILSON, R. Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria. Nature 274, 701–703 (1978). https://doi.org/10.1038/274701a0
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DOI: https://doi.org/10.1038/274701a0
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