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Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum

Nature volume 294, pages 366–368 (1981)Cite this article

Abstract

Two types of dopamine receptor whose stimulation affects cellular cyclic AMP have now been identified. In tissues as different as insect ganglia and mammalian neostriatum, stimulation of the dopamine receptor called D-1 increases formation of cyclic AMP1–6, whereas stimulation of the second type of dopamine receptor (D-2)7–11, first identified in the rat pituitary gland, reduces cyclic AMP formation. Recently, a receptor with the pharmacological properties of the D-2 receptor has also been found12–14 in the rat neostriatum; we show here that stimulation of this receptor is followed by a reduction in cyclic AMP formation induced by V stimulation with D-1 agonists.

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References

  1. Harmar, A. J. & Horn, A. S. Molec. Pharmac. 13, 512–520 (1977).

    CAS  Google Scholar 

  2. Kebabian, J. W., Petzold, G. L. & Greengard, P. Proc. natn. Acad. Sci. U.S.A. 69, 2145–2149 (1972).

    Article  ADS  CAS  Google Scholar 

  3. Brown, E. M., Carroll, R. J. & Aurbach, G. D. Proc. natn. Acad. Sci. U.S.A. 74, 4210–4213 (1977).

    Article  ADS  CAS  Google Scholar 

  4. Watling, K. J. & Dowling, J. E. J. Neurochem. 36, 559–568 (1981).

    Article  CAS  Google Scholar 

  5. Kebabian, J. W. & Greengard, P. Science 174, 1346–1349 (1971).

    Article  ADS  CAS  Google Scholar 

  6. Kebabian, J. W. & Calne, D. B. Nature 277, 93–96 (1979).

    Article  ADS  CAS  Google Scholar 

  7. DeCamilli, P., Macconi, D. & Spada, A. Nature 278, 252–254 (1979).

    Article  ADS  CAS  Google Scholar 

  8. Giannattasio, G., DeFerrari, M. E. & Spada, A. Life Sci. 28, 1605–1612 (1981).

    Article  CAS  Google Scholar 

  9. Munemura, M., Eskay, R. L. & Kebabian, J. W. Endocrinology 106, 1795–1803 (1980).

    Article  CAS  Google Scholar 

  10. Cote, T. E., Grewe, C. W. & Kebabian, J. W. Endocrinology 108, 420–426 (1981).

    Article  CAS  Google Scholar 

  11. Munemura, M., Cote, T. E., Tsuruta, K., Eskay, R. L. & Kebabian, J. W. Endocrinology 107, 1676–1683 (1980).

    Article  CAS  Google Scholar 

  12. Sibley, D. R. & Creese, I. Endocrinology 107, 1405–1409 (1980).

    Article  CAS  Google Scholar 

  13. Creese, I., Schneider, R. & Snyder, S. H. Eur. J. Pharmac. 46, 377–381 (1977).

    Article  CAS  Google Scholar 

  14. Stefanini, E., DeVoto, P., Marchisio, A. M., Vernaleone, F. & Collu, R. Life Sci. 26, 583–587 (1980).

    Article  CAS  Google Scholar 

  15. Forn, J., Krueger, B. K. & Greengard, P. Science 186, 1118–1120 (1974).

    Article  ADS  CAS  Google Scholar 

  16. Sala, G. B., Hayashi, K., Catt, K. J. & Dufau, M. L. J. biol. Chem. 254, 3861–3865 (1979).

    CAS  PubMed  Google Scholar 

  17. Tait, J. F., Tait, S. A. S. & Bell, J. B. G. Essays Biochem. 16, 99–174 (1980).

    CAS  PubMed  Google Scholar 

  18. Beavo, J. A. et al. Molec. Pharmac. 6, 597–603 (1970).

    CAS  Google Scholar 

  19. Mulder, A. H., Van den Berg, W. B. & Stoof, J. C. Brain Res. 99, 419–424 (1975).

    Article  CAS  Google Scholar 

  20. Setler, P., Sarau, H. M., Zerkle, C. L. & Saunders, H. L. Eur. J. Pharmac. 50, 419–430 (1978).

    Article  CAS  Google Scholar 

  21. Brown, E. M. et al. Molec. Pharmac. 18, 335–340 (1980).

    CAS  Google Scholar 

  22. Scapagnini, U. et al. in Sulpiride and Other Benzamides (eds Spano, P.F., Trabucchi, M., Corsini, G. U. & Gessa, G. L.) 193–205 (Italian Brain Research Foundation, Milan, 1979).

    Google Scholar 

  23. Spano, P. F., Stefanini, E., Trabucchi, M. & Fresia, P. in Sulpiride and Other Benzamides (eds Spano, P. F., Trabucchi, M., Corsini, G. U. & Gessa, G. L.) 11–31 (Italian Brain Research Foundation, Milan, 1979).

    Google Scholar 

  24. Bach, N. J. et al. J. med. Chem. 23, 481–491 (1980).

    Article  CAS  Google Scholar 

  25. Tsuruta, K. et al. Nature 292, 463–465 (1981).

    Article  ADS  CAS  Google Scholar 

  26. MacLeod, R. M. in Frontiers in Endocrinology Vol. 4 (eds Martini, L. & Ganong, W. F.) 169–194 (Raven, New York, 1976).

    Google Scholar 

  27. Caron, M. G. et al. J. biol. Chem. 253, 2244–2253 (1978).

    CAS  Google Scholar 

  28. Alexander, R. W., Davis, J. N. & Lefkowitz, R. J. Nature 258, 437–440 (1975).

    Article  ADS  CAS  Google Scholar 

  29. Dowling, J. E. & Watling, K. J. J. Neurochem. 36, 569–579 (1981).

    Article  CAS  Google Scholar 

  30. König, J. F. R. & Klippel, R. A. in The Rat Brain : A Stereotaxic Atlas (Krieger, New York, 1970).

    Google Scholar 

  31. Harper, J. F. & Brooker, G. L. J. Cyclic Nucleotide Res. 1, 207–218 (1975).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20205, USA

    J. C. Stoof & J. W. Kebabian

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  1. J. C. Stoof
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  2. J. W. Kebabian
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Stoof, J., Kebabian, J. Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum. Nature 294, 366–368 (1981). https://doi.org/10.1038/294366a0

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