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Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin–neurophysin II precursor

Nature volume 295, pages 299–303 (1982)Cite this article

Abstract

The sequence of a cDNA encoding the nonapeptide arginine vasopressin (A VP) and its carrier protein, neurophysin II (NpII) from bovine hypothalamus, proves that the 166-amino acid precursor molecule contains a signal peptide of 19 amino acids followed directly by A VP connected to NpII by a Gly-Lys-Arg sequence. The carboxy-terminal region of the precursor contains a naturally occurring glycopolypeptide of 39 amino acids which is separated from NpII by a single arginine residue.

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Authors and Affiliations

  1. Institut für Zell- und Tumorbiologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900, Heidelberg, FRG

    Hartmut Land & Günther Schütz

  2. Institut für Physiologische Chemie, Abteilung Zellbiochemie, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg, 20, FRG

    Hartwig Schmale & Dietmar Richter

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  1. Hartmut Land
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Land, H., Schütz, G., Schmale, H. et al. Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin–neurophysin II precursor. Nature 295, 299–303 (1982). https://doi.org/10.1038/295299a0

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